艾司西酞普兰片联合百乐眠胶囊对慢性失眠伴焦虑抑郁的临床观察-神经病学专业论文.docxVIP

万方数据 目 录 中文摘要·······································································································1 英文摘要·······································································································3 英文缩写·······································································································6 研究论文 艾司西酞普兰片联合百乐眠胶囊对慢性失眠伴焦虑抑郁的临床 观察 前言·······································································································7 对象与方法···························································································9 结果·····································································································11 附表·····································································································13 讨论·····································································································17 结论·····································································································22 参考文献·····························································································23 综述 百乐眠胶囊治疗肝郁阴虚型失眠伴发焦虑抑郁的研究················26 致谢····························································································??·················38 个人简历······································································································39 中 文 摘 要  PAGE 5 万方数据 艾司西酞普兰片联合百乐眠胶囊对慢性失眠伴 焦虑抑郁的临床观察 摘 要 目的：观察艾司西酞普兰片联合百乐眠胶囊治疗慢性失眠伴焦虑抑郁 的效果。 方法：选取 2013 年 6 月-2015 年 6 月就诊于河北医科大学第一医院 睡眠障碍门诊主诉失眠（符合 ICD-10 失眠症诊断标）的患者，病程大于 6 个月，并经汉密尔顿抑郁量表(HAMD24)、汉密尔顿焦虑量表(HAMA14) 评测伴有焦虑抑郁的 100 例患者作为研究对象。随机分为对照组和联合治 疗组，每组 50 例，其中对照组患者单用艾司西酞普兰片进行治疗，联合 治疗组患者采用艾司西酞普兰片联合百乐眠胶囊进行治疗。所有患者服用 右佐匹克隆，2 组患者各治疗 8 周，应用 HAMD24、HAMA14 和匹兹堡睡 眠质量指数（PSQI）对患者治疗前后、2 周末和 8 周末焦虑抑郁情绪和睡 眠质量进行评价，通过 HAMD24、HAMA14 和 PSQI 减分率比较两组患者 的治疗总有效率，比较两种治疗方法对患者的睡眠质量和焦虑抑郁情绪的 疗效和不良反应。 结果： 1 治疗前两组患者的一般资料 入选的 100 例患者中，男 36 例，女 64 例。年龄 32-84 岁，平均年 龄 48.5 ??6.9 岁。平均病程 8.0 ??1.2 个月。将所有患者随机分为两组，联合 组 50 例，其中男性 19 例，女性 31 例，平均年龄 56