选择性β1―受体阻滞剂治疗慢阻肺患者荟萃分析.docVIP

选择性β1―受体阻滞剂治疗慢阻肺患者荟萃分析 　　[摘要] 目的 ?ρ≡裥驭?1-受体阻滞剂治疗慢阻肺患者的荟萃进行分析，通过多层次的观察达到相应的预防治疗的效果。 方法 方便选择 2016 年 1 月―2017 年 10 月该院内科住院治疗的 88 例AECOPD 合并 CHF 患者作为研究对象。将 AECOPD 合并 CHF 患者随机分为对照组和观察组，对照组采用常规治疗，观察组在常规治疗的基础上加用富马酸比索洛尔，治疗开始前和治疗后第 11 天采血检测 BNP 和蛋白定量值的分析。 结果 观察组患者的治疗总有效率高于对照组，差异有统计学意义（P0.05）。结论 在选择性β1 -受体阻滞剂的过程中，对β1-受体的亲和力比对 β2 -受体强 11～34 倍，需要对β1-受体阻滞剂的优点进行全面性的发挥，并在各种层面的对照组的分析中使得整体的受体阻滞剂治疗效果更加显著。 　　[关键词] 选择性β1受体阻滞剂；慢阻肺患者；荟萃分析 　　[中图分类号] R563.05 [文献标识码] A [文章编号] 1674-0742（2018）03（b）-0104-03 　　A Meta-analysis of Selective β1-receptor Blockers in Patients with Chronic Obstructive Pulmonary Disease 　　XIE Tian-cheng 　　The Third Hospital Department of respiration， Zhangzhou City， Fujian Province， Zhangzhou， Fujian Province， 363000 China 　　[Abstract] Objective To analyze the meta-analysis of selective beta 1- blockers in the treatment of chronic obstructive pulmonary disease， and to achieve the corresponding preventive and therapeutic effects through multi-level observation. Methods 88 cases of AECOPD combined with CHF were convenient selected from January 2016 to October 2017 in our hospital. AECOPD patients with CHF were randomly divided into control group and observation group， control group with conventional treatment， the observation group in the conventional treatment plus bisoprolol， analysis of eleventh samples were measured BNP and protein values before treatment and after treatment. Results The observation group the total efficiency is higher than the control group， the difference was statistically significant（P0.05）. Concludion In the selective β1-blockers， the affinity of β1-receptors is 11 to 34 times stronger than that of β2-receptors， and it is necessary to comprehensively evaluate the advantages of β1-blockers. Play， and in a variety of levels of control group analysis makes the overall effect of receptor blocker treatment more significant. 　　[Key words] Selective β1 blockers； Patients with COPD； Meta-analysis 　　慢性阻塞性肺疾病（COPD）是一种具有气流受限特征的疾病，在整体的疾病防控中，需要根据烟