超声造影在评价颈动脉粥样硬化斑块稳定性中应用价值.docVIP

超声造影在评价颈动脉粥样硬化斑块稳定性中应用价值 　　【摘要】 目的：探讨超声造影在评价颈动脉粥样硬化斑块稳定性中的应用价值。方法：52例颈动脉粥样硬化斑块患者依据临床症状分为有症状组（35例）和无症状组（17例），根据超声回声分为软斑块20例，混合斑块18例，硬斑块14例。比较斑块构成、造影增强强度（EI）、斑块与管腔增强强度比值（ratio）及和造影增强程度分级。结果：有症状组软斑块比例明显高于无症状组，造影后EI及ratio值明显高于无症状组；软斑块造影Ⅲ级比例、EI及ratio值均高于混合斑块及硬斑块，而混合斑块造影Ⅲ级比例、EI及ratio值高于硬斑块，比较差异均有统计学意义（P0.05）。结论：超声造影可通过观察颈动脉粥样硬化斑块内新生血管情况而定量评估斑块的稳定性。 　　【关键词】 颈动脉粥样硬化斑块； 超声造影； 脑梗死； 稳定性 　　【Abstract】 Objective： To explore the application value of contrast-enhanced ultrasound in the evaluation of the stability of carotid atherosclerotic plaques. Method： 52 patients with carotid atherosclerotic plaques were divided into symptomatic group （35 cases） and asymptomatic group （17 cases） according to clinical symptoms， and divided into 20 cases of soft plaque， 18 cases of mixed plaque and 14 cases of hard plaque according to the ultrasonic echo. The plaque composition， contrast enhanced intensity （EI）， plaque and lumen enhanced intensity ratio （ratio） and contrast enhancement degree classification of each groups were compared. Result： The ratio of soft plaque in symptomatic group was significantly higher than that of the asymptomatic group， and after contrast EI and ratio values was significantly higher than that of the asymptomatic group （P0.05）. The proportion of soft plaque imaging Ⅲ， EI and ratio values was higher than that of the mixed plaque and hard plaque， and the proportion of mixed plaque contrast Ⅲ， EI and ratio values was higher than that of hard plaque （P0.05）. Conclusion： Contrast enhanced ultrasound can enhance quantitative assessment of the stability of plaque through observing the neovascularization in carotid atherosclerotic plaques. 　　【Key words】 Carotid atherosclerosis； Ultrasonography； Cerebral infarction； Stability 　　First-author’s address： The Hospital of Wuhan University of Science and Technology， Wuhan 430065， China 　　doi：10.3969/j.issn.1674-4985.2015.07.045 　　颈动脉粥样硬化斑块脱落所致颅内动脉严重栓塞是诱发脑梗死的主要原因，其稳定性则是决定患者病情严重程度的主要因素，故准确评估斑块性质，对确诊、监测疾病进展及预防脑梗死发生等各方面均具有重要的临