银丹心脑通软胶囊对糖尿病周围神经病变伴高血压患者神经生长因子影响.docVIP

银丹心脑通软胶囊对糖尿病周围神经病变伴高血压患者神经生长因子影响 　　[摘要] 目的 探讨银丹心脑通软胶囊对糖尿病周围神经病变伴高血压患者神经生长因子的影响。 方法 选取糖尿病周围神经病变伴高血压患者130例，随机分为对照组和观察组，各65例。两组均给予常规治疗，对照组在常规治疗的基础上口服甲钴胺片，观察组在对照组治疗的基础上加用银丹心脑通软胶囊治疗。治疗2个月后评定疗效。 结果 治疗后，观察组患者神经传导速度（NCV）高于对照组，差异有统计学意义（P0.01）。观察组患者胰岛素样生长因子-1（IGF-1）水平高于对照组、血管内皮细胞生长因子（VEGF）水平低于对照组，差异有统计学意义（P0.01）。观察组总有效率为83.08%，高于对照组的61.53%，差异有统计学意义（P0.01）。观察组患者的物质生活、社会功能、心理功能以及生存质量总分均高于对照组，差异有统计学意义（P0.01）。 结论 银丹心脑通软胶囊治疗糖尿病周围神经病变伴高血压效果确切，能提高周围神经传导功能，改善周围神经功能状态，从而改善患者的生活质量。 　　[关键词] 糖尿病周围神经病变；高血压；银丹心脑通软胶囊；神经生长因子；神经传导速度 　　[中图分类号] R587.1 [文献标识码] A [文章编号] 1674-4721（2014）09（c）-0061-04 　　The influence of Yindan Xinnaotong capsule on nerve growth factor of patients with diabetic peripheral neuropathy and hypertension 　　LUO Yue-dong1 LUO Jun-ming2 　　1.Department of Endocrinology，Taihe County Hospital of Traditional Chinese Medicine in Jiangxi Province，Taihe 343700，China；2.Department of Endocrinology，the Second Affiliated Hospital of Nanchang University，Nanchang 330006，China 　　[Abstract] Objective To study on the effect of Yindan Xinnaotong capsule on nerve growth factor of patients with diabetic peripheral neuropathy and hypertension. Methods 130 cases of patients with diabetic peripheral neuropathy and hypertension were selected，and divided into observation group and control group，65 cases in each group.All patients were given with routine treatment，mecobalamin tablet was taken to the control group，Yindan Xinnaotong capsule was added to the observation group on the basis of control group.The efficacy was evaluated after two months treatment. Results After treatment，nerve conduction velocity （NCV） of the observation group was higher than that of the control group，the difference was significant （P 　　[Key words] Diabetic peripheral neuropathy；Hypertension；Yindan Xinnaotong capsule；Nerve growth factor；Nerve conduction velocity 　　糖尿病周围神经病变是糖尿病最常见的并发症[1]，是造成糖尿病患者死亡的重要原因之一。有研究报道[2]，银丹心脑通软胶囊治疗糖尿病周围神经病变效果显著。本研究探讨银丹心脑通软胶囊对糖尿病周围神经病变伴高血压患者神经生长因子的影响。 　　1 资料与方法 　　1.1 一般资料 　　选择2010年7月～2