靶控输注丙泊酚复合盐酸羟考酮用于无痛肠镜临床观察.docVIP

靶控输注丙泊酚复合盐酸羟考酮用于无痛肠镜临床观察 　　[摘要] 目的 观察靶控输注丙泊酚复合羟考酮在无痛肠镜检查中的效果。 方法 选择无痛肠镜患者60例随机分为芬太尼组（F组，n=30）和盐酸羟考酮组（O组，n=30）。F组采用芬太尼1 μg/kg静脉注射，丙泊酚以血浆靶浓度4 μg/mL静脉输注，待患者睫毛反射消失后设置靶浓度2.5 μg/mL持续泵注。肠镜检查开始后如患者体动则设置为3 μg/mL。O组采用盐酸羟考酮注射液10 mg稀释为1 mg/mL，0.1 mg/kg静脉注射后丙泊酚以4 μg/mL靶控输注。分别于麻醉前（T0）、麻醉1 min（T1）、手术开始时（T2）、术毕15 min（T3），监测血压、心率、呼吸频率、氧饱和度、体动，整个过程托下颌辅助通气并记录术后恶心呕吐例数。 结果 F组和O组两组间呼吸频率于 T1时比较有统计学差异，SPO2无统计学差异。F组术中出现3例体动，2例术后恶心呕吐，与O组比较有统计学差异（P0.05）。结论 靶控输注丙泊酚复合盐酸羟考酮用于肠镜检查具有血流动力学稳定，呼吸抑制轻，术后并发症少的优点。 　　[关键词] 肠镜检查；靶控输注；羟考酮注射液；并发症 　　[中图分类号] R614.2 [文献标识码] B [文章编号] 1673-9701（2018）07-0115-03 　　[Abstract] Objective To observe the effect of target-controlled infusion of propofol combined with oxycodone in painless colonoscopy. Methods Sixty patients taking painless colonoscopy were randomly divided into fentanyl group （n=30） and oxycodone hydrochloride group（n=30）. Group F was received intravenous injection of fentanyl （1 μg/kg） and propofol （4 μg/mL： The plasma target concentration）. After the eyelash reflex disappeared， injection was continued（the target concentration was 2.5 μg/mL）. After starting the colonoscopy， if the patients body moved， the amount was set to 3 μg/mL. O group was injected with oxycodone hydrochloride， 10 mg oxycodone hydrochloride injection was diluted to 1 mg/mL， 0.1 mg/kg for intravenous infusion and propofol was target-control infused with 4 μg/mL. Blood pressure， heart rate， respiratory rate， oxygen saturation， body motion were monitored before anesthesia（T0）， 1 minute after anesthesia（T1）， at the beginning of operation （T2） and 15 minutes after operation（T3）. Assisted ventilation by holding up the underjaw and record the number of cases with nausea and vomiting. Results There was statistically difference in respiratory rate between the two groups at T1， but there was no statistical difference in SPO2. There were 3 cases of body movement in group F， and 2 cases of postoperative nausea and vomiting， which had statistically significant difference compared with group