铜绿假单胞菌和鲍曼不动杆菌临床分布和耐药性分析.docVIP

铜绿假单胞菌和鲍曼不动杆菌临床分布和耐药性分析 　　[摘要] 目的 调查分析医院2012～2013年铜绿假单胞菌和鲍曼不动杆菌的临床分布及耐药性，为临床合理使用抗菌药物和及早预防和控制医院感染提供科学依据。 方法 回顾性统计2012年1月～2013年12月嘉兴地区两所综合性三甲医院中分离的铜绿假单胞菌和鲍曼不动杆菌的临床资料，进行耐药性分析。 结果 铜绿假单胞菌和鲍曼不动杆菌分离率以痰液最高，分别占68.35%和81.79%；科室分布铜绿假单胞菌以呼吸内科为主（17.65%），鲍曼不动杆菌以ICU为主（19.03%）；铜绿假单胞菌对亚胺培南和美洛培南的耐药率呈逐年上升趋势，分别从8.45%、8.09%上升到13.10%、11.16%；鲍曼不动杆菌对头孢吡肟、亚胺培南、美洛培南、头孢哌酮/舒巴坦、左氧氟沙星等抗菌药物耐药率为19.36%～32.80%，对氨曲南、头孢曲松的耐药率达90%。 结论 铜绿假单胞菌和鲍曼不动杆菌是医院最常见的条件致病菌，临床应加强耐药性监测，减少多重耐药菌的产生，避免院内感染和暴发流行。 　　[关键词] 铜绿假单胞菌；鲍曼不动杆菌；抗菌药物；耐药性 　　[中图分类号] R378.9 [文献标识码] A [文章编号] 1673-7210（2015）06（a）-0020-05 　　Clinical distribution and drug resistance analysis of pseudomonas aeruginosa and acinetobacter baumanmii 　　WANG Yahua1 ZHU Yongming2 WU Xiaoyan3 SONG Xiulan4 LI Xumei2 CHEN Songjin3 FENG Xuejun3 SHAO Pingyang3 　　1.Department of Pharmacy， the First Hospital of Jiaxing， Zhejiang Province， Jiaxing 314001， China； 2.Department of Pharmacy， the Second Hospital of Jiaxing， Zhejiang Province， Jiaxing 314000， China； 3.Department of Laboratory， the Second Hospital of Jiaxing， Zhejiang Province， Jiaxing 314000， China； 4.Department of Laboratory， the First Hospital of Jiaxing， Zhejiang Province， Jiaxing 314001， China 　　[Abstract] Objective To investigate the clinical distribution and drug resistance of pseudomonas aeruginosa and acinetobacter baumanmii in hospital during 2012-2013， and provide scientific basis for rational use of antibiotics in clinic and early prevention-control of hospital infections. Methods Retrospective statistics were performed for the clinical data of pseudomonas aeruginosa and acinetobacter baumannii detached from two comprehensive three-grade hospitals during January 2012 to December 2013 in Jiaxing， then drug resistance was analyzed. Results The detach rates of pseudomonas aeruginosa and acinetobacter baumannii were the highest in sputum， was 68.35% and 81.79% separately. Pseudomonas aeruginosa was mainly distributed in respiration medicine （17.65%）， and acinetobacter baumannii was mainly distri