重组人酸性成纤维细胞生长因子配合Q开关NdYAG激光治疗老年斑研究.docVIP

重组人酸性成纤维细胞生长因子配合Q开关NdYAG激光治疗老年斑研究 　　【摘要】 目的 评价重组人酸性成纤维细胞生长因子（rh-aFGF）配合 Q开关Nd：YAG 激光治疗老年斑的临床疗效及安全性。方法 107例老年斑患者， 随机分为两组， 应用 MedliteⅣ型美肤激光治疗仪， 以1064 nm波长， 2～4 mm光斑照射， 1次/周， 10周为1个总疗程。治疗组给予重组人酸性成纤维细胞生长因子， 溶于20 ml生理盐水冲洗激光术后创面后持续喷雾治疗（3～4 喷/cm2， 6～8次/d）， 连续应用7 d；对照组仅给予生理盐水冲洗及喷雾。采用CK34-MPA9型多功能皮肤测试仪检测治疗前后经皮水分丢失（TEWL）、含水量以及皮肤黑色素量， 并评价激光术后并发症。结果 治疗组总有效率高于对照组（96.4% VS 90.2%）， 差异具有统计学意义（P0.05）， 采用rh-aFGF治疗后皮肤TEWL 值和黑色素指数相比于对照组下降明显。另外治疗组对激光引起的红斑、水肿、色素沉着具有一??的减少作用。结论 rh-aFGF配合激光术应用， 可显著提高老年斑治疗疗效， 减少激光术后并发症。 　　【关键词】 重组人酸性成纤维细胞生长因子；老年斑；激光 　　【Abstract】 Objective To evaluate the efficacy and safety of recombinant human acidic fibroblast growth factor （rh-aFGF） and Q-switch Nd：YAG laser in the treatment of senile plaques. Methods A randomized controlled clinical study was conducted among 107 patients with senile plaques. Patients were randomly divided into two groups， and were treated by MedliteⅣQ-switch Nd：YAG laser with 1064nm wavelength， 2-4mm spot， once a week and 10 weeks for a period of treatment. Then， the treatment group was treated by aerosol therapy of rh-aFGF dissolved in 20 ml normal saline on wound （3～4 spray/cm2， 6～8 times/day） for 7 days. The control group was treated with normal saline. Both groups were detected of the transepidermal water loss （TEWL）， moisture content and the amount of melanin in the skin before and after the treatment using CK34-MPA9 multi-functional skin tester and postoperative complications of laser treatment were evaluated. Results The total effective rate of the treatment group was higher than the control group （96.4% VS 90.2%）， and the difference had statistical significance （P0.05）. The TEWL and the melanin value after rh-aFGF treatment of the treatment group decreased obviously， compared with the control group. Besides， erythema， edema and pigmentation which caused by laser treatment were all decreased in the treatment group. Conclusion The Treatment of rh-aFGF and laser can significantly increase the curative effect on senile plaques，