阿托伐他汀对终末期肾脏病及心功能临床价值.docVIP

阿托伐他汀对终末期肾脏病及心功能临床价值 　　[摘要] 目的 探讨阿托伐他汀对终末期肾脏病患者脑钠肽及心功能的影响。 方法 选取本院2011年10月～2013年10月诊治的终末期肾脏病患者106例，根据治疗方案分为两组，53例患者实施常规治疗为对照组，53例患者加用阿托伐他汀为观察组，疗程12周。于治疗前后使用彩色多普勒超声检测患者的左室射血分数和左室舒张末期内径，比较两组患者治疗前后的脑钠肽水平和心功能指标，分析两组患者的不良反应情况。 结果 治疗后，两组患者脑钠肽、左室舒张末期内径均显著减小，而左室射血分数显著增加。观察组患者脑钠肽、左室舒张末期内径均明显小于对照组，观察组患者左室射血分数明显高于对照组，差异均有统计学意义（P＜0.05）。观察组患者不良反应发生率高于对照组，差异无统计学意义（P＞0.05）。 结论 阿托伐他汀可明显改善终末期肾脏病患者的心功能，降低脑钠肽水平，不良反应少且安全性高，值得临床推广使用。 　　[关键词] 阿托伐他汀；终末期肾脏病；脑钠肽；心功能；临床价值 　　[中图分类号] R692.5#8195;#8195;#8195;[文献标识码] B#8195;#8195;#8195;[文章编号] 2095-0616（2014）09-100-03 　　 　　Clinical value of atorvastatin on brain natriuretic#160;peptide and heart function of patients with end stage renal#160;disease 　　BAI#8195;Heng#8195;#8195;ZHOU#8195;Wei 　　Department of Renal#160;Internal Medicine, Peoples Hospital of Xingcheng City in Liaoning Province, Xingcheng 125100, China 　　[Abstract] Objective To investigate influence of atorvastatin on brain natriuretic#160;peptide and heart function in patients with end stage renal#160;disease. Methods 106 patients with end stage renal disease were selected in hospital from October 2011 to October 2013. According to treatment, patients were divided into two groups.53 patients#160;received routine treatment#160;as control group.53 patients combined with atorvastatin as observation group.Course of treatment was 12 weeks. Left ventricular ejection fraction and left#160;ventricular end diastolic diameter were detected by color doppler ultrasound before and after treatment. Brain natriuretic peptide and cardiac#160;function indexes were compared between two groups before and after treatment. Adverse#160;reactions were analyzed in two groups. Results After treatment,#160;brain natriuretic#160;peptide and left#160;ventricular end diastolic diameter significantly reduced while left ventricular ejection fraction significantly increased in two groups.#160;Brain natriuretic#160;peptide and left#160;ventricular end diastolic diameter in observation group were significantly