阿托伐他汀联合高压氧治疗慢性硬膜下血肿临床研究.docVIP

阿托伐他汀联合高压氧治疗慢性硬膜下血肿临床研究 　　[摘要] 目的 观察阿托伐他汀联合高压氧治疗慢性硬膜下血肿的临床疗效。 方法 将120例慢性硬膜下血肿患者随机分为治疗组60例和对照组60例。两组患者入组后均予高压氧治疗，治疗组在高压氧治疗基础上加用阿托伐他汀治疗，每次1片（20 mg），口服，每日1次，疗程8周。治疗2个月后，比较两组临床疗效和不良反应。比较治疗前后Barthel指数（BI）、改良Rankin评分（mRS）、临床症状和CT影像情况，评估临床疗效。 结果 治疗后，治疗组BI（79.2±12.6）分，mRS评分（1.6±0.5）分；对照组BI（68.3±11.2）分，mRS评分（2.4±1.3）分，两组治疗后BI及mRS评分比较，差异均有统计学意义（P0.05）；治疗组总有效率为73.3%（44/60），对照组总有效率为55.0%（33/60），差异有统计学意义（P0.05）。两组均未出现严重不良反应。 结论 临床上阿托伐他汀联合高压氧可有效治疗慢性硬膜下血肿，且安全性较好。 　　[关键词] 阿托伐他汀；高压氧；慢性硬膜下血肿；安全性 　　[中图分类号] R651.15 [文献标识码] A [文章编号] 1673-9701（2018）03-0019-03 　　Clinical study of atorvastatin combined with hyperbaric oxygen therapy in the treatment of chronic subdural hematoma 　　YANG Fan ZHOU Gezhi TONG Minfeng 　　Department of Neurosurgery， Jinhua Central Hospital in Zhejiang Province， Jinhua 321000， China 　　[Abstract] Objective To observe the clinical efficacy of atorvastatin combined with hyperbaric oxygen therapy in the treatment of chronic subdural hematoma. Methods 120 patients with chronic subdural hematoma were randomly divided into the treatment group（60 cases） and the control group（60 cases）. Two groups of patients were treated with hyperbaric oxygen therapy. The treatment group was further given atorvastatin on the basis of hyperbaric oxygen therapy， with one tablet（20 mg） orally once a day for 8 weeks. After 2 months of treatment， the clinical efficacy and adverse reactions in the two groups were compared. Barthel Index （BI）， modified Rankin score （mRS）， clinical symptoms and CT imaging were compared before and after treatment to evaluate the clinical efficacy. Results After treatment， the BI was（79.2±12.6） points， and the mRS score was（1.6±0.5） points in the treatment group； the BI was（68.3±11.2） points， and the mRS score was（2.4±1.3） points in the control group. After comparing the BI and mRS score of the two groups， the differences were statistically significant（P0.05）. The total effective rate in the treatment group was 73.3%（44/60）， and 55.0% in the control group（3