高压氧治疗对新生儿缺氧缺血性脑病血清IL6及TNFα影响.docVIP

高压氧治疗对新生儿缺氧缺血性脑病血清IL6及TNFα影响 　　[摘要] 目的：探讨高压氧（HBO）治疗新生儿缺氧缺血性脑病（HIE）对血清白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）的影响。方法：将246例新生儿缺氧缺血性脑患儿随机分为常规治疗组和高压氧治疗组，常规治疗组给予常规支持和对症治疗，高压氧治疗组在常规治疗的基础上加用高压氧治疗。比较两组治疗前后的血清IL-6、TNF-α水平的变化。结果：两组治疗前IL-6、TNF-α水平比较差异均无统计学意义。治疗后两组的血清IL-6、TNF-α水平均降低，但高压氧治疗组上述指标下降幅度较常规组明显(P＜0.05)。结论：HBO治疗HIE有较好疗效，HBO治疗HIE可能是通过降低IL-6、TNF-α水平而减轻脑细胞损害的。 　　[关键词] 新生儿；缺氧缺血性脑病；高压氧；白细胞介素-6；肿瘤坏死因子-α 　　[中图分类号] R722[文献标识码]A [文章编号]1673-7210（2010）11（a）-025-02 　　 　　Hyperbaric oxygen therapy influence on serum IL-6 and TNF-α of 　　hypoxic ischemic encephalopathy 　　LIN Jitao 　　(Guangdong Province Shenzhen Bao′an District Peoples Hospital, Shenzhen 518101, China) 　　[Abstract] Objective: To explore hyperbaric oxygen therapy influence on serum IL-6 and TNF-α of hypoxic ischemic encephalopathy. Methods: 246 cases of HIE were randomly divided into conventional treatment group and hyperbaric oxygen therapy group, conventional treatment group was given regular support and symptomatic treatment, while hyperbaric oxygen therapy group given conventional treatment and hyperbaric oxygen therapy. Level change of serum IL-6 and TNF-α was compared before and after the treatment of the two groups. Results: The level of IL-6 and TNF-α had no statistically significant differences before treatment of the two groups. The level of serum IL-6 and TNF-α reduced after treatment in the two groups, but the above indexes in hyperbaric treatment group had significant difference than that in conventional group (P＜0.05). Conclusion: HBO therapy on HIE has good curative effect, HBO therapy may reduce level of IL-6 and TNF-α and lighten brain cell damage. 　　[Key words] Neonatal; Hypoxic ischemic encephalopathy; Hyperbaric oxygen; IL-6; TNF-α 　　 　　新生儿缺氧缺血性脑病(hypoxic ischemic encephalopathy，HIE)是儿科临床上常见的一种神经系统疾病，其发病率、致残率、死亡率均很高。其发病机制包括能量负荷减少、离子失衡、兴奋性毒性、钙离子超载、自由基的产生等。已有文献表明IL-6和TNF-α参与了HIE的发生与发展[1]。大量报道显示高压氧是治疗HIE的有效手段，本文旨在探讨高压氧治疗HIE对IL-6、TNF-α的影响[2]，现报道如下： 　　1 对象与方法 　　1.1 研究对象 　　我院新生儿监护病房（NICU）于2006年1月～2009