高压氧联合纳洛酮治疗急性一氧化碳中毒50例临床分析.docVIP

高压氧联合纳洛酮治疗急性一氧化碳中毒50例临床分析 　　[摘要] 目的 探讨高压氧联合纳洛酮治疗急性一氧化碳中毒的临床疗效。 方法 回顾性分析本院2012年3月～2015年3月收治的100例一氧化碳中毒患者的临床资料，根据治疗方法的不同将其随机分为观察组和对照组各50例。所有患者入院后均先进行抢救，如保持患者呼吸通畅，稳定血压，进行呼吸机辅助高压吸氧，积极防治并发症，维持脑部神经的营养状态，促进细胞功能的恢复。对照组仅进行上述基础治疗，观察组患者除进行上述治疗外，再给予纳洛酮治疗。观察两组患者的临床有效率、昏迷时间、迟发性脑病发生情况以及病死率。 结果 对照组痊愈12例，有效23例，有效率70.0%；观察组痊愈25例，好转20例，有效率90.0%，两组比较差异有统计学意义（P0.05）。 结论 高压氧联合纳洛酮治疗急性一氧化碳中毒临床疗效较好，能进一步改善患者的预后。 　　[关键词] 高压氧；纳洛酮；急性一氧化碳中毒；迟发性脑病；昏迷 　　[中图分类号] R595.1 [文献标识码] B [文章编号] 1673-9701（2016）21-0104-03 　　[Abstract] Objective To evaluate the clinical effect of hyperbaric oxygen and naloxone in treatment of acute carbon monoxide poisoning patients. Methods The clinical data of 100 cases of acute carbon monoxide poisoning patients in our hospital from Mar 2012 to Mar 2015 were analyzed retrospectively. Patients were divided into control group and observation group（each 50 cases） according to the therapeutic methods. All the patients were received emergency treatment such as keep upper airway patency， maintenance of blood pressure， ventilator assisted hyperbaric oxygen inhalation， prevention of complications， maintain the nutritional status of the brain， promotion of the recovery of cell function. The control group patients were received only the conventional treatment， while the patients in observation group were further received naloxone treatment. The clinical effective rates， coma time， incidence of delayed encephalopathy， mortality were compared. Results The total efficiency of the control group was 70.0%， including 12 cases of full recovery and 23 cases of improvement. While the total efficiency of the observation group was 90.0%， including 25 cases of full recovery and 20 cases of improvement， there was statistical significant between the two groups（P0.05）. Conclusion The clinical effect of hyperbaric oxygen combined with naloxone exhibit on acute carbon monoxide poisoning patients is good and can further improve the prognosis for the patients. 　　[Key words] Hyperbaric oxygen； Na