食管鳞癌IGF―1REGFR蛋白表达及其临床意义.docVIP

食管鳞癌IGF―1REGFR蛋白表达及其临床意义 　　【摘要】 目的 研究IGF-1R、EGFR蛋白在食管鳞癌患者中的表达情况及其临床意义。方法 应用免疫组织化学SP法检测50例食管鳞癌患者IGF-1R、EGFR蛋白的表达情况， 取20例手术标本正常组织作为对照组。结果 食管鳞癌中IGF-1R蛋白阳性表达率明显升高（χ2=28.29， P0.05）， EGFR蛋白阳性表达率明显升高（χ2=4.56， P0.05）。IGF-1R的阳性表达与食管癌的病理分级有关， 分级越高阳性率越高， 与浸润深度有关， 侵及深肌层及外膜IGF-1R的表达明显高于侵及浅肌层及黏膜的表达， 与TNM分期有关， 分期越晚阳性率越高， 差异均有统计学意义。淋巴结转移组IGF-1R或EGFR的表达明显高于非转移组。结论 初步结果分析显示IGF-1R可能与食管鳞癌的病理分级及侵袭、转移有关， EGFR可能与食管鳞癌的转移有关。 　　【关键词】 食管癌；IGF-1R蛋白；EGFR蛋白；免疫组织化学 　　Expression and significance of IGF-1R and EGFR protein in esophageal squamous carcinoma ZHANG Jun-kai， PAN Pei-ling， WU Ying-meng. Department of Oncology， Peoples Hospital of Zhongshan， Zhongshan 528403，China 　　【Abstract】 Objective To investigate the expression of IGF Type 1 Receptor protein and EGFR protein in esophageal squamous carcinoma patients and its clinical significance. Methods The expressions of IGF-1R and EGFR protein were detected in 50 patients with esophageal squamous carcinoma， 20 cases of normal esophageal tissue by SP immunohistochemistry method. Results The positive rate of IGF-1R protein was markedly higher in esophageal squamous carcinoma than in normal esophageal tissue. （χ2=28.29， P=0.032）. The positive rate of EGFR protein was also higher. （χ2=4.56， P0.05）. Close correlation was found on the expression of IGF-1R between pathological grade of esophageal squamous carcinoma，the invasion of tumor and TNM stages. Difference was statistically significant. The expression of IGF-1R or EGFR was higher in lymph node metastasis positive patients than that in negative patients. Conclusion The expression of IGF-1R protein has some relationship with the pathological grade， invasion， metastasis and esophageal squamous carcinoma. The expression of IGF-1R protein has some relevance with the metastasis of esophageal squamous carcinoma. 　　【Key words】 Esophageal carcinoma； IGF Type 1 Receptor protein； EGFR protein； Immunohistochemistry 　　本文应用免疫组化的方法研究IGF-1R和EGFR在食管鳞癌中的异常表达，对食管鳞癌中使用靶向治疗具有积极意义。 　　1 资料与方法 　　1. 1 一般资料 入选50病例