鼓室注射类固醇激素治疗突发性耳聋疗效研究.docVIP

鼓室注射类固醇激素治疗突发性耳聋疗效研究 　　【摘要】 目的：探讨鼓室注射类固醇激素（甲基泼尼松龙）对中老年突发性耳聋患者（SSNHL）的临床疗效。方法：选取2011年8月-2014年8月在笔者所在医院耳鼻喉科收治的116例老年突发性耳聋患者作为研究对象，根据患者意愿将其分为鼓室注射组76例（76耳）和静脉注射组40例（40耳），鼓室注射组采用鼓室注射甲基泼尼松龙治疗，静脉注射组采用静脉注射甲基泼尼松龙治疗，其余给予相同处理。观察比较两组患者的临床治疗效果。结果：经治疗后，鼓室注射组的治疗总有效率68.4%明显高于静脉注射组的42.5%，差异有统计学意义（P0.05）。在有全身伴发疾病的患者中，鼓室注射组的治疗总有效率80.0%明显高于静脉注射组的41.7%，差异有统计学意义（P0.05）；在无伴发疾病的患者中，鼓室注射组的治疗总有效率76.1%明显高于静脉注射组的42.9%，差异有统计学意义（P0.05）。结论：鼓室注射类固醇激素治疗中老年突聋更为有效，尤其对于伴有糖尿病、心脑血管疾病的患者，可减少全身用药不良反应，值得临床推广。 　　【关键词】 突发性耳聋； 甲基泼尼松龙； 鼓室注射； 静脉注射 　　中图分类号 R764.437 文献标识码 B 文章编号 1674-6805（2015）11-0028-03 　　【Abstract】 Objective：To investigate the clinical effect of intratympanic intravenous injection steroid hormones （Methyllprednisolone） for sudden sensorineural heating-loss （SSNHL） in the elderly.Method：116 elderly patients with sudden deafness admitted to our hospital from August 2011 to August 2014 were selected as research objects.According to the wishes of patients，they were divide into the intratympanic injection group for 76 cases（76 ears） and the intravenous group for 40 cases（40 ears）.The intratympanic injection group was treated with intratympanic Methyllprednisolone injection，the intravenous group was treated with intravenous injection of Methyllprednisolone，other interventions consistent.The clinical effect of the two groups were observed and compared.Result：After treatment，the total efficiency of treatment in the intratympanic injection group was 68.4%，which was significantly higher than 42.5% in the intravenous group，the difference was statistically significant（P0.05）.The total efficiency of sudden deafness in intratympanic injection group with systemic comorbid disease was 80.0%，which was significantly higher than 41.7% in the intravenous group，the difference was statistically significant（P0.05）.The total efficiency of sudden deafness in intratympanic injection group without comorbid diseases was 76.1%，which was significantly higher than 42.9% in the intravenous group，the difference was statis