高通量血液透析对维持性血液透析患者钙磷代谢及皮肤瘙痒影响.docVIP

高通量血液透析对维持性血液透析患者钙磷代谢及皮肤瘙痒影响 　　【摘要】 目的：观察高通量血液透析对维持性血液透析患者钙磷代谢及皮肤瘙痒的影响。方法：选择笔者所在医院2014年1月-2015年1月收治的维持性血液透析（MHD）患者80例为研究对象，随机分为两组，每组40例。分别给予低通量血液透析（LFHD）和高通量血液透析（HFHD）治疗，随访观察6个月，检测患者试验前、试验后6个月体内血清钙、磷及甲状旁腺激素（PTH）水平的变化，以及皮肤瘙痒的程度。结果：HFHD组患者经6个月治疗后，血磷、PTH水平较试验前均明显下降，差异均有统计学意义（P0.05）；LFHD组患者在试验前后血钙、磷、PTH水平均无明显变化，差异均无统计学意义（P0.05）；HFHD组患者在随访观察结束时，与LFHD组比较，血磷、PTH均明显降低，差异均有统计学意义（P0.05）；MHD患者经HFHD治疗后，皮肤瘙痒程度较试验前明显减轻，差异有统计学意义（P0.05）。结论：HFHD能明显改善MHD患者体内钙磷代谢紊乱，进而改善皮肤瘙痒程度。 　　【关键词】 高通量血液透析； 血钙； 血磷； 甲状旁腺激素； 皮肤瘙痒 　　中图分类号 R692.5 文献标识码 A 文章编号 1674-6805（2016）25-0003-03 　　【Abstract】 Objective：To observe the effect of high flux hemodialysis（HFHD） on calcium-phosphate metabolism and skin pruitus in maintenance hemodiaylsis patients. Method：A total of 80 maintenance hemodialysis patients admitted to our hospital from January 2014 to January 2015 were enrolled and randomly divided into two groups，40 patients in each group.They were received low flux hemodialysis（LFHD） and HFHD respectively for 6 months respectively.The serum calcium，phosphorus and parathyroid hormone and skin pruitus in these maintenance hemodialysis patients were examined at the baseline and in the follow-up period of 6 months.Result：After treatment for 6 months，there were significant differences in the levels of serum phosphorus and parathyroid hormone（P0.05）.However，the levels of serum calcium，phosphorus and parathyroid hormone were not changed obviously in LFHD group compared to its levels before，the difference had no statistically significant（P0.05）.Furthermore，the differences of serum phosphorus and parathyroid hormone in the HFHD group were lower than those of the LFHD group after treatment for 6 months，the differences were statistically significant（P0.05）.The skin pruitus was improved significantly after changing to HFHD in maintenance hemodialysis patients compared with LFHD groups，the difference was statistically significant（P0.05）.Conclusion：HFHD can improve the calcium-phosphate metabolism in maintenance hem