高通量血液透析对糖尿病肾病维持性血液透析患者氧化应激和微炎症状态影响.docVIP

高通量血液透析对糖尿病肾病维持性血液透析患者氧化应激和微炎症状态影响 　　[摘要] 目的 研究高通量血液透析对糖尿病肾病维持性血液透析患者氧化应激和微炎症状态的影响。方法 该次研究选取的研究对象为2016年2月―2017年2月期间在该院进行治疗的78例糖尿病肾病维持性血液透析患者，将78例患者计算机随机分为两组，39例/组。将实施普通血液透析的患者纳入对照组，将采用高通量血液透析的患者设为观察组。对两组糖尿病肾病维持性血液透析患者的氧化应激指标、微炎症状态相关指标进行比对。结果 观察组糖尿病肾病维持性血液透析患者治疗12周和治疗24周时的MDA、SOD、T-AOC、CRP、TNF-α、IL-6同对照组相比均匀差异有统计学意义（P0.05）。结论 糖尿病肾病维持性血液透析患者应用高通量血液透析进行治疗能够使氧化应激状态和微炎症状态减轻。 　　[关键词] 糖尿病肾病；维持性血液透析；氧化应激；微炎症状态；高通量血液透析 　　[中图分类号] R692.5 [文献标识码] A [文章编号] 1672-4062（2017）09（b）-0001-02 　　Effect of High-flux Hemodialysis on the Oxidative Stress and Microinflammatory State of Patients with Diabetic Kidney Disease Maintain Sex Blood Dialysis 　　HAN Xiao-wen 　　Baotou Central Hospital， Baotou， Inner Mongolia， 014040 China 　　[Abstract] Objective To research the effect of high-flux hemodialysis on the oxidative stress and microinflammatory state of patients with diabetic kidney disease maintain sex blood dialysis. Methods 78 cases of patients with diabetic kidney disease maintain sex blood dialysis in our hospital from February 2016 to February 2017 were selected as the research objects and randomly divided into two groups with 39 cases in each， the control group adopted the common blood dialysis， while the observation group adopted the high-flux hemodialysis， and the oxidative stress indicators and microinflammatory state relevant indicators were compared between the two groups. Results The differences in the MDA，SOD，T-AOC，CRP，TNF-α，IL-6 levels at 12 weeks and 24 weeks after treatment of patients between the observation group and the control group were obvious（P0.05）. Conclusion The application of high-flux hemodialysis in patients with Diabetic kidney disease Maintain sex blood dialysis can relieve the oxidative stress state and microinflammatory state. 　　[Key words] Diabetic kidney disease； Maintain sex blood dialysis； Oxidative stress； Microinflammatory state； High-flux hemodialysis 　　?S持性血液透析一般应用在肾病患者的治疗中，但患者会存在氧化应激状态，尤其是糖尿病肾病患者更加严重；另外氧化应激与糖尿病肾病维持性血液透析患者慢性炎症、心血管并发症的发生存在密切关