叶酸维生素B6与维生素B12治疗冠心病并高同型半胱氨酸血症患者40例临床观察.docVIP

叶酸维生素B6与维生素B12治疗冠心病并高同型半胱氨酸血症患者40例临床观察 　　[摘要] 目的:评价叶酸、维生素B6和维生素B12对治疗高同型半胱氨酸(Hcy)血症及冠心病的临床疗效。方法:将冠心病伴高同型半胱氨酸血症患者78例随机分为两组,对照组给予常规治疗,治疗组在常规治疗基础上加用叶酸、维生素B6和维生素B12片,1个疗程1个月,对治疗前后血清同型半胱氨酸水平、临床表现及心电图进行观察。结果:治疗后两组空腹血清同型半胱氨酸水平分别为(25.9±8.1) μmol/L和(17.8±7.6) μmol/L,两组比较差异有统计学意义(P0.01),且治疗组总有效率达90.0%,优于对照组的55.3%,两组比较差异有统计学意义(P0.05)。结论:口服叶酸片、维生素B6和维生素B12片可以有效降低血清同型半胱氨酸浓度,且对冠心病有显著疗效。 　　[关键词] 叶酸;维生素B6;维生素B12;高同型半胱氨酸;冠心病 　　[中图分类号] R972 [文献标识码]B [文章编号]1674-4721(2010)04(b)-044-02 　　 　　Clinical observation of folic acid,VitB6 and VitB12 on the treatment of high homocysteine type coronary artery disease 　　LUO Haipan 　　(Department of Medicine, Health Center of Fenglang,Dabu 514200, China) 　　[Abstract] Objective: To appraise the effective of folic acid, VitB6 and VitB12 on high homocysteine of coronary heart disease. Methods: There were 78 cases randomly divided into the treatment group (routine treatment added Folic Acid, VitB6 and VitB12) and control group(routine treatment), the course of treatment was one month for both groups, observed Hcy, clinical manifestation and ECG prior treatment and post treatment. Results: The Hcy level in treatment group and control group was (25.9±8.1) μmol/L and (17.8±7.6) μmol/L,and total effective rate in two groups was 90.0% and 55.3%. Treatment group was superior to the control group in relaxation rate of Hcy level and ative effect. Conclusion: Folic acid,VitB6 and VitB12 are effective on high Hcy type coronary artery disease. 　　[Key words] Folic acid; VitB6; VitB12; Homocysteine; Coronary artery disease 　　 　　近年来发现高同型半胱氨酸(Hcy)血症与冠状动脉粥样硬化性心脏病的发生密切相关,为了解降低血清同型半胱氨酸能否降低冠心病的危险性或改善冠心病病情,本科采用叶酸、维生素B6和维生素B12干预治疗冠心病伴高同型半胱氨酸血症患者40例,发现有显著疗效,现报道如下: 　　1 资料与方法 　　1.1 一般资料 　　选择2007年12月～2009年12月广东大埔枫朗镇卫生院,按世界卫生组织(WHO)《缺血性心脏病的命名和诊断标准》[1]确定诊断为冠心病并有高血清同型半胱氨酸患者78例,且所有研究对象都已排除其他风湿性疾病、肝肾功能不全及肿瘤等病史或有影响Hcy水平药物服药史(如甲氨喋呤、卡马西平、苯妥英、一氧化二氮、6-氮尿嘧啶苷等)。随机分为两组,治疗组40例,男22例,女18例;年龄45~76岁,平均63岁;治疗前Hcy水平为(30.8±9.2) μmol/L。对照组38例,男20例,女18例;年龄44~77岁,平均62岁;治疗前Hcy水平为(29.7±9.