后程加速超分割与腔内加速照射治疗局部晚期宫颈癌临床研究.docVIP

后程加速超分割与腔内加速照射治疗局部晚期宫颈癌临床研究 　　【摘要】目的 评估后程加速超分割放射治疗和腔内加速照射治疗局部晚期宫颈癌可行性和毒副反应。方法 随机将60例局部晚期宫颈癌患者分为后程加速超分割放射治疗、腔内加速照射组（第1组，共30例）和经典常规放射治疗组（第2组，共30例），二组均辅助多西紫杉醇70mg/m2d1+顺铂70mg/Md2×2化疗，比较二组总治疗时间、近期疗效及毒副反应。结果 二组总治疗时间分别为48.64±4.96天和56.32±3.56天（p＜0.001），盆腔复发二组各1例（复发时间分别为12个月和7个月），两组无瘤生存率及早期并发症相似，晚期并发症（放射性直肠炎Ⅱ级）二组各1例，均无统计学意义。结论后程加速超分割放射治疗和腔内加速照射治疗局部晚期宫颈癌并不增加放射治疗毒副反应，但能明显缩短总治疗时间，对于提高局部晚期宫颈癌的局部控制率和对远期生存率可能有益。 　　【关健词】超分割 腔内后装 宫颈癌 放射治疗 　　中图分类号：R737.3文献标识码：A文章编号：1005-0515（2011）2-038-03 　　Clinical Observation Of Late Course Accelerated Hyperfractionated Radiotheray And brachytherapyFor Locally Advanced Cervical Cancer 　　 Luo taoying Wu haigen Li longyu 　　(Department of Oncology, Jiangxi Provincial Women and Childrens Health Hospital ,Nanchang 330006 , China) 　　【Abstract】The purpose of this study was to assess the feasibility and toxicity of late course accelerated hyperfractionated radiotheray and brachytherapyfor locally advanced cervical cancerMethods Random 60 patients with locally advanced cervical cancer were divided into late course accelerated hyperfractionated radiotheray and brachytherapy ( group 1, n=30) and classical conventional radiotherapy and (group 2 ,n=30), to compare two groups of the overall treatment time , short-term curative effect and the side reaction. Results Two groups of overall treatment time respectively were 48.64±4.96 and 56.32±3.56days (p 0.001), pelvic recurrence occurred in two Groups ,but only have 1 case. (recurrence time for 12 months and 7 months,respectively ), Late complication( rectal bleeding) occurred only in Group 1 ，but was self-limited . disease-free survival rate and early complications were similar in both groups, both of two groups have 1 case with acceptable grade 2 late radiation proctitis complications,but were not statistically significant.Conclusion late course accelerated hyperfractionated radiotheray and brachytherapy for locally advanced cervical cancer did not increase the radiotherapy adverse reaction, But can obv