男性不育症患者精浆丙二醛与超氧化物岐化酶活性测定及临床价值研究.docVIP

男性不育症患者精浆丙二醛与超氧化物岐化酶活性测定及临床价值研究 　　[摘要] 目的 研究测定男性不育患者精浆MDA、SOD活性的临床价值。 方法 120例患者采用随机数字表法分为三组，健康对照组、白细胞精子症组和少弱精子症组，比较MDA、SOD活性。 结果 少弱精子症组与白细胞精子症组精浆MDA明显高于健康对照组；白细胞精子症组精浆MDA明显高于少弱精子症组，差异有统计学意义（P0.01）。少弱精子症组与白细胞精子症组精浆SOD明显低于健康对照组（P0.01）；白细胞精子症组精浆SOD明显低于少弱精子症组（P0.01）。 结论 ROS是导致男性不育症的一个重要病因，男性不育患者精浆MDA和SOD的测定对男性不育症的诊断具有重要的临床价值。 　　[关键词] 男性不育症；精浆；超氧化物岐化酶；丙二醛 　　[中图分类号] R446.1 [文献标识码] A [文章编号] 2095-0616（2017）16-242-03 　　Clinical significance of seminal plasma MDA and SOD activity in infertile patients 　　CHEN Junying1 HUANG Qingyong1 ZHANG Meixue1 DENG Longsheng2 　　1.Clinical Laboratory，Xiamen Hospital of Traditional Chinese Medicine，Xiamen 361009，China；2.Department of Andrology，Xiamen Hospital of Traditional Chinese Medicine，Xiamen 361009，China 　　[Abstract] Objective To observe the clinical significance of seminal plasma MDA and SOD activity in infertile patients. Methods 120 patients were randomly divided into three groups，healthy control group，leukocytospermia group and oligoasthenozoospermia group.The MDA，SOD activity were compared. Results The seminal plasma MDA of oligoasthenozoospermia group and leukocytospermia group were significantly higher than that of healthy control group.The seminal plasma MDA of leukocytospermia group was significantly higher than that of oligoasthenozoospermia group （P0.01）.The seminal plasma SOD of oligoasthenozoospermia group and leukocytospermia group were significantly lower than that of healthy control group （P0.01）.The seminal plasma SOD of leukocytospermia group was significantly lower than that of oligoasthenozoospermia group （P0.01）. Conclusion ROS is an important cause of male infertility.The determination of seminal plasma MDA and SOD in male infertility patients has important clinical value in the diagnosis of male infertility. 　　[Key words] Male infertility；Seminal plasma；Superoxide dismutase；Malondialdehyde 　　活性氧（Reactive oxygen species，ROS）引起脂?|过氧化损伤导致精子结构和功能损害是男性不育症的一个重要原因，越来越受到临床医师的关注[1-2]。本研究拟通过检测白细胞精子症和少弱精子症患者精浆中反映脂