杜仲的植物雌激素活性成分研究-生药学专业论文.docxVIP

ABSTRACT 也 ( 咱 11 4 Du Zhong，the cortex of Eucommia ulmoides Oli队， has beenωed to strengthen the Iiver and kidneys ，bones，tocolysis，lower blood pressure and antifatigue. So it is used for treating liver and kidney deficiency，weak waist，impotence，hypertension ， hemorrhage of pregnancy and so on. Eucommia ulmoides belongs to a single species genus in the plant family Eucommiaceae. It is an economical plant native ωChina， while Korea and Japan start introducting in recent years. Eucommia ulmoides Oliv. is a deciduous tree，upωtwenty me臼rs. After break the bark and leaves have fine silver flexible plastic wire. Some 衍aditional Chinese medicine which can strengthen the liver and kidneys， bones show phytoestrogenic activity and theirs phytoestrogenic constituents are lignans， flavonoi巾， stilbenes and 50 on. Eucommia ulmoides can strengthen the Iiver and kidneys，bones and its chemical ωmposition is mainly lignans and flavonoi巾， so we choose it to do research. By solvent extraction，recrystallization ，polyamide ，silica gel and macroporous resin column chromatography，eighteen compounds were isolated 仕om 白e ethanol extracts of Eucommia ulmoides. The s仕uctures of sixteen compounds were identified by NMR， MS and comparing with authentic samples including two lignans，four iridoids， three flavonoids，two 位iterpenoids，four anthraquinones and a sterol.They are sitosterol (EUC-l)，betulinic acid (EUC-2)，betulín (EU巳匀， wogonin (EUC-4)，aloe emodin (EUC-5)，oroxylinA (EUC-6)，genipin (EUC-7)，baicalein (EUC8)，emodin (EUC-9)， chrysophanol (EUC-l1)，physcion (EUι12)，geniposide (EUB30-1)，geniposidic acid (EUB30-匀， aucubin (EUB30-3)，pinoresinol di-O-P-D-glucopyranoside (EUB30-4) and syringaresinol di-O币-D-glucopyranoside (EUB30-5). Among these compounds， wogonin (EUC叶)， aloe emodin (EUC-匀， oroxylinA (EUC-6)，baicalein (EUC-8)， emodin (EUC-9)，chrysophanol (EUC斗 1) and physcion (EUC12) were the first found in Eucommia ulmoid