人类珠蛋白基因簇表达的转录调控-生命科学研究.PDF

1 1 Vol. 1, No. 1 1997 12 Life Science Research Dec. 1997 杨友云　　朱定尔 ( , , 4 10078) 人类 珠蛋白基因簇的表达具有明显时空调控特征, 即具有严格的 系 组织特异性和不同发育阶段特异性, 同时尚需精确调控, 以使 / 珠蛋白链合成比趋 向平衡并定量聚合成功能蛋白k 血 蛋白. 因此, 它是研究真核基因表达调控及基因 表达与细胞分化关系的理想模型. 本文拟综述在转录水平人类珠蛋白基因表达调控 研究的进展, 并对该领域的发展方向进行预测, 以期逐步深入研究并最终阐明其表达 调控机制. 并籍此文报道近年来我们在此领域研究的新成果、新概念. 珠蛋白基因簇表达, 转录调控, 、- 基因间调控区或网络, 顺式作用元 件, 基质结合区 7 3 Q The Transcription Regulation of The Expression of - Human Globin Gene Cluster Yang YouyunZhu Dinger ( , , , , 4 10078, ) Molecular Biology Research Center Hunan Medical University Changsha Hunan PRC AbstractThe expression of human - globin gene cluster is definitely regulated w ith strict developmental stage and tissue lineage specificities as w ell as the delicated control of the / biosynthetic equilibrium of globins in order to be polymerized for their function protein k . - hemoglobin The expression and regulation of the human globin gene cluster is an ide- al model for studying the regulation of the eukariocytic gene expression and its relation w ith cell differentiation. T his paper presents a latest review of the progress of the studies of ex- - pression and its regulation of globin gene cluster at transcription level and some ad- vanced studies are discussed as w ell. By the way , w e w ould like to report excitedly some of our recent research achievements and novel concepts in this field. Key words- globin gene clus