上海政府公务员血尿酸水平和代谢综合征相关性研究.docVIP

上海政府公务员血尿酸水平和代谢综合征相关性研究 　　 【摘要】 目的探讨上海政府公务员血尿酸水平与肥胖、血压、血脂、血糖等代谢综合征各组分的关系。 方法选取2007年至2009年在我院进行健康体检的上海政府公务员共3563例,测定和统计分析腰围、收缩压、舒张压、血尿酸、空腹血糖、空腹胰岛素、TC、TG、LDL?C、HDL?C等指标。 结果男性和女性公务员组的高尿酸血症患病率分别为26.7%和14.8%( P 0.001);男性公务员组的腰围、收缩压、舒张压、TC、TG、LDL?C、GLU和HOMA?IR均随血尿酸水平的升高而显著升高( P 0.05),HDL?C则显著降低( P =0.034);女性公务员组的腰围、收缩压、舒张压、TG、LDL?C、GLU和HOMA?IR均随血尿酸水平的升高而升高( P 0.05),而TC、HDL?C差异无统计学意义(P值分别为0.218和0.146)。 结论血尿酸水平与肥胖、血脂异常、血压、血糖及胰岛素抵抗等MS组分之间关系密切,控制血尿酸水平是代谢综合征治疗中的重要环节之一。 　　 【关键词】 　　高尿酸血症;代谢综合征 　　 ?? 　　Correlations between serum uric acid level and components of metabolic syndrome in the civil servants of Shanghai 　　 　　WAN Peng?cheng,GUAN Guo?yue,LI Jin?yu.Department of Gerontology,Shanghai Huadong Sanatorium,Wuxi 214065,China 　　 　　 【Abstract】 ObjectiveTo investigate the correlations between serum uric acid(SUA)levels and components of metabolic syndrome in the civil servants of Shanghai. Methods3563 civil servants of Shanghai underwent health examination in our hospital 2007?2009 were selected,Waist circumference(WC),SBP,DBP,SUA,GLU,fasting serum insulin(FINS),TC,TG,LDL?C and HDL?C were measured and analyzed statistically. ResultsThe prevalence rates of hyperuricemia in male and female were 26.7%and 14.8%respectively( P 0.001).For male,WC,SBP,DBP,TC,TG,LDL?C,GLU and HOMA?IR increased significantly with increasing the level of SUA( P 0.05),while HDL?C decreased significantly( P =0.034).For female,WC,SBP,DBP,TG,LDL?C,GLU and HOMA?IR increased significantly with increasing the level of SUA( P 0.05),while there were no significant differences between TC,HDL?C and SUA( P =0.218 andP =0.146,respectively). ConclusionSerum uric acid was closely related to components of metabolic syndrome.Controlling SUA was one of the crucial steps in the treatment of metabolic syndrome. 　　 【Key words】 　　Hyperuricemia; Metabolic syndrome 　　 　　随着人们生活水平的提高、生活方式的改变,高尿酸血症(Hyperuricemia,HUA)的发病率呈逐年升高趋势[1,2]。近年来,研究表明高尿酸血症不仅能诱发痛风性关节炎、尿石症、尿酸性肾病,它与高血压、高脂血症、糖尿病、冠心病等心血管疾病密切相关[3]。本研究对3563例上海市政府公务员的血尿酸