α―硫辛酸和钴胺联合治疗糖尿病周围神经病变68例疗效对比分析.docVIP

α―硫辛酸和钴胺联合治疗糖尿病周围神经病变68例疗效对比分析 　　[摘要] 目的 观察α-硫辛酸与甲钴胺合用治疗糖尿病周围神经病变的疗效。方法 将68例确诊为2型糖尿病合并周围神经病变的患者作为观察对象，并随机分组，治疗组和对照组各34例，在控制血糖和改善循环的基础上，治疗组给予α-硫辛酸和甲钴胺联合治疗，对照组给予甲钴胺治疗，疗程2周，对照两组治疗前后临床疗效和神经传导速度的变化。结果 治疗组显效14例，有效18例，总有效率94.1%，对照组显效7例，有效11例，?有效率67.6%（P0.05）。治疗前后两组患者神经传导速度差异有统计学意义（P0.05）。 结论 α-硫辛酸联合甲钴胺治疗糖尿病周围神经病变较单用甲古胺疗效显著。 　　[关键词] 糖尿病周围神经病变；硫辛酸；甲钴古胺 　　[中图分类号] R587.2 [文献标识码] A [文章编号] 1672-4062（2017）01（b）-0076-03 　　[Abstract] Objective To observe the curative effect of α- protagen and cobalamin in treatment of diabetic neuropathy. Methods 68 cases of patients with type 2 diabetes and diabetic neuropathy were selected and randomly divided into two groups with 34 cases in each， the treatment group were treated withα- protagen and cobalamin on the basis of controlling blood sugar and improving the circulation， while the control group were treated with mecobalamin on the basis of controlling blood sugar and improving the circulation， and the treatment course was 2 weeks， and the clinical curative effect and nerve conduction velocity changes before and after treatment were compared between the two groups. Results In the treatment group， 14 cases were markedly effective and 18 cases were effective， and the total effective rate was 94.1%， in the control group， 7 cases were markedly effective and 11 cases were effective， and the total effective rate was 67.6%（P0.05）， and the difference in the nerve conduction velocity between the two groups before and after treatment was obvious（P0.05）. Conclusion The curative effect ofα- protagen and cobalamin in treatment of diabetic neuropathy is more obvious than the single cobalamin. 　　[Key words] Diabetic neuropathy；Protagen； Cobalamin 　　我国自改革开放以来，经济迅速发展，城乡居民的生活水平有了质的飞跃，生活方式的改变和人口的老龄化，使糖尿病的发病率也逐年上升，2007年中国糖尿病的发病率是9.7%，至2010年这一数字上升到11.6%，已成为继心脑血管疾病后危害人类健康的第3位疾病。糖尿病作为一种慢性代谢性疾病，如果长期血糖控制不良可导致多种慢性并发症，而糖尿病围神经病变是其最常见的慢性并发症之一，大约50.0%的糖尿病周围神经病变患者无症状且早期体征不明显，常不易引起患者的重视。据统计，糖尿病患者病程在10年左右的发病率约50%，病程在20年者发病率高达90%，因此，对糖尿病患者及早发现其周围神经病变并进行有效的治疗，提高患者的生