老年高血压患者踝臂指数和下肢外周动脉疾病相关性研究.docVIP

老年高血压患者踝臂指数和下肢外周动脉疾病相关性研究 　　【摘要】目的通过测量踝臂指数(Ankle-Brachial Index,ABI)评价老年高血压患者下肢外周动脉病(Peripheral arterial disease,PAD)的发病情况,并对老年高血压PAD 的危险因素进行评价。方法本研究678例(男326例)老年高血压患者进行踝臂指数(ABI)测量,患者均来湘雅三医院及湘潭市中心医院。ABI≤0.9为诊断PAD的标准。年龄、性别、体重指数、血压、血脂、血尿酸等均视为临床变量,作为PAD的危险因素分析。对临床变量和PAD的关系采用单变量和多变量Logistic回归分析。结果老年高血压患者PAD发生率35.5%,PAD患者男性为42.3%显著低于女性57.7%(P0.05)。老年高血压患者PAD合并糖尿病发生率46.1%、吸烟者48.1%、冠心病病史者54.8%、以及收缩压151.46±23.53和舒张压80.55±12.37均显著高于非PAD组(P0.05);单变量和多变量Logistic回归分析表明上述临床指标、血尿酸、血脂、空腹血糖以及高血压分级为PAD的独立危险因素。结论老年高血压患者中,PAD发病率较高;同时合并其他危险因素的老年高血压患者PAD发病率明显增高;ABI可作为高危人群筛查与监测的有效方法。 　　【关键词】踝臂指数外周动脉病危险因素高血压 　　中国图分类号:R 文献标识码:A 文章编号:1005-0515(2010)08-060-04 　　Association of ankle brachial index with the peripheral arterial disease in aged patients with hypertension 　　Huang haobo*, Yuan hong2, Zeng jianping1, Huang zhijun2, Long hui3, Fu sang3.. 　　*Department of Cardiology, Xiangtan central hospital, Xiangtan 411100, China 　　【Abstract】ObjectThe aim of this study was to evaluate the prevalence and risk factors of peripheral arterial disease (PAD) in aged patients with hypertension by measuring the ankle-brachial index (ABI).Subject and MethodsA total of 678 aged patients with hypertension were recruited from Third Xiangya Hospital and Xiangtan city central hospital. PAD was diagnosed by an ankle-brachial index (ABI)≤0.9 on either leg. Clinical variables studied were age, sex, body mass index (BMI), smoking, blood pressure, blood lipid and uric acid. Multivariate logistic regression analysis was made to explore the association of the clinical variables with PAD. 　　ResultsHiger prevalence of aged hypertension patients with PAD was 35.5%, significant lower men: women ratio (42.3% vs. 57.7%) than prevalence of patients without PAD (P0.05). Prevalence of diabetes, coronary artery disease, smorking, systolic blood pressure and diastolic blood pressure were, respectively, 46.1%, 48.1%, 54.8%, 151.46±23.53 mmHg and 80.55±12.37 mmHg in patients with PAD, significantly higher than those witho