多西他赛联合奈达铂治疗晚期上皮性卵巢癌临床的研究.docVIP

多西他赛联合奈达铂治疗晚期上皮性卵巢癌临床的研究 　　摘要：目的： 探讨多西他赛联合奈达铂治疗晚期卵巢癌的临床疗效及其毒副反应。方法： 选取2011年1月~2013年6月我校附属肿瘤医院收治的90例晚期上皮性卵巢癌，随机分为研究组和对照组，研究组采用多西他赛联合奈达铂化疗方案治疗，对照组采用多西他赛联合顺铂方案治疗，21天为1个疗程，治疗均在2个疗程以上，观察其临床疗效及不良反应。结果： 经过化疗2个疗程后，研究组有21例腹水恢复正常，治疗有效率为73.33％；对照组有17例腹水恢复正常，有效率为68.89%。研究组与对照组所出现的副反应相似，经过对症处理后均缓解或者痊愈。结论： 多西他赛联合奈达铂化疗方案治疗晚期上皮性卵巢癌疗效明显，不良反应可以接受，可作为晚期卵巢癌的化疗方案之一。?? 　　 　　关键词：多西他赛；奈达铂；晚期上皮性卵巢癌；化疗?? 　　 　　ClinicaI investigation of docetaxel combined with nedaplatin in the treatment of On Advanced epithelial ovarian cancer ?? 　　 　　 Wu Chong?? 　　 　　 Abstract:Objective: To evaluate the efficacy and safety of concomitant docetaxal(DTX) and nedaplatin(NDP)therapy for on advanced epithelial ovarian cancer.Methods 90 cases of advanced epithelial ovarian carcinoma admitted in the affiliated cancer hospital of CSU from January, 2011 to June, 2013 were selected and randomly divided into research group and control group. Patients in the research group were treated with docetaxal plus nedaplatin while patients in the control group were treated with docetaxal and cisplatin one treatment cycle last for 21 days, all the patients were treated for more than 2 treatment cycles, the therapeutic effect and adverse reactions were observed and evaluated.Results: After 2 treatment cycles, the effective rate of research group was 73.33%, 21 cases of ascites subsidised, but the effective rate of control group was 68.89%, just 17 cases of ascites subsidised. The incidences of adverse reactions in both groups were similar, which were all relieved or cured after symptomatic treatment.Conclusion: Docetaxal plus nedaplatin had an obvious therapeutic effect on advanced epithelial ovarian cancer, and the adverse reactions were endurable, it could be used as a selective chemotherapy regime for advanced epithelial ovarian cancer.?? 　　 　　 key words: Docetaxal ；Nedaplatin; Advanced epithelial ovarian cancer; chemotherapy 　　 　　【中图分类号】R737.3 【文献标识码】A 【文章编号】1672-8602(2014)05-0005-02?? 　　卵巢癌是严重威胁妇女健康的主要恶性肿瘤之一，其发