苍术二陈汤治疗AECOPD的临床疗效观察及对血清8isoPGF2α GSH水平的影响-中西医结合;呼吸内科专业论文.docxVIP

- - PAGE 3 - ABSTRACT Purpose Through clinical comparison between acetylcysteine and decoction of Cang Zhu Erchen , to observe the decoction of Cang Zhu Erchen clinical efficacy in acute exacerbation of COPD and oxidative stress parameters of 8 - iso prostaglandin F2α (8 - iso-PGF2α) and the lines glutathione (GSH) levels. And confirmed Cang Zhu Erchen herbs efficacy and safety by clinical observation. Method The 30 patients met the chronic obstructive pulmonary disease mild, severe diagnostic criteria, which belong to Feizhang in TCM were randomly divided into treatment group and control group. Two groups were treatment with oxygen, antibiotics, bronchodilators agents , necessary glucocorticoid. Treatment group: In addition to the above treatment measures, to oral decoction 100ml tid; control group: In addition to the above treatment measures, to oral acetylcysteine particles 0.2g tid. Course of treatment in both groups were 10 days. Before and after treatment were observed clinical efficacy, TCM syndrome scores, the improvement in lung function and before and content 8-iso-PGF2α, GSH in serum. Results By comparing symptoms of AECOPD before and after treatment, we can firmly believe that the symptoms can be effectively improved(the statistical significant P0.05 ). By comparing TCM syndrome scores before and after treatment ,it can be concluded that the TCM syndrome scores is extremely improved(the statistical significant P0.05 ). By comparing FEV1% before and after treatment, the FEV1% was improved effectively(the statistical significant P0.05 ). By comparing content of 8-iso-PGF2α、GSH in serum before and after treatment, there is no evident difference. Conclusion After the clinical observation, we can get into the conclusion that the Cangzhu Erchen Decoction has significant effect on improving the symptoms, TCM syndrome scores and pulmonary function of patients with AECOPD. However, there is no specific influence on content of 8-iso-PGF2α、GSH i