儿童咳嗽变异性哮喘转为典型哮喘的危险因素分析-儿科学专业论文.docxVIP

儿童咳嗽变异性哮喘转为典型哮喘的 危险因素分析 研究生：李 涛 导师：张卫平 教授 摘 要 目的：探讨本地区儿童咳嗽变异性哮喘转为典型哮喘的危险因素，为预防其发 展为典型哮喘提供理论依据。方法：对 2009 年 4 月~2010 年 9 月就诊于我院的 180 例咳嗽变异性哮喘患儿进行 6 个月的随访，分析相关影响因素的参与，包括性别、 年龄、种族、病情轻重、持续时间、特应性体质、家族哮喘史、居住环境、被动吸 烟、近期呼吸道感染、对治疗的依从性，观察咳嗽变异性哮喘发展为典型哮喘的情 况。对于随访结果，首先对有关变量进行单因素非条件 Logistic 回归分析，然后将单 因素分析中有显著性意义的变量进行多因素非条件 Logistic 回归分析，以估计各危险 因素的相对危险度。结果：180 例咳嗽变异性哮喘患儿发展为典型哮喘的为 46 例， 发生率为 25.56%，经单因素非条件 Logistic 回归分析显示，典型哮喘的发生与特应 性体质、家族哮喘史、居住环境不良、被动吸烟、近期呼吸道感染、对治疗的依从 性有关，与性别、年龄、种族、病情轻重、持续时间无关。多因素非条件 Logistic 回归分析表明，特应性体质、家族哮喘史、近期呼吸道感染、对治疗的依从性差可 能是咳嗽变异性哮喘发展为典型哮喘的危险因素。结论：特应性体质、家族哮喘史、 近期呼吸道感染、对治疗的依从性差可能是咳嗽变异性哮喘患儿发展为典型哮喘的 危险因素，提示早期充分认识，并积极控制相关的危险因素，可以改善患儿的预后， 减少典型哮喘的发生。 关键词：儿童；咳嗽变异性哮喘；典型哮喘；危险因素 The study on risk factors of childhood cough variant asthma changed into classical asthma Postgraduate: Li Tao Supervisor: Prof. Zhang Weiping Abstract Objective：To investigate the risk factors at the process of childhood cough variant asthma changed into classical asthma,and provides theory to prevent cough variant asthma change into classical asthma. Methods：The patients of cough variant asthma were received treatment in our hospital from April 2009 to September 2010,and had been followed up for 6 months,analyse the roles of the related factors（including gender、age、 race、illness weight、duration、atopic asthma physique、family history、the living environment、passive smoking、recent respiratory infection、and the compliance of treatment）at the process of cough variant asthma changed into classical asthma. For the result,first of relevant variables to single factor unconditional Logistic regression analysis,then,will the single factor analysis of meaningful variables,more factors unconditional Logistic regression analysis to estimate various risk factors. Result：The 180 cases cough variant asthma patients changed into classical asthma for 46 cases,the rate is about 25.56%.The single factor unconditional Logistic regression analysis shows that the process is connected with atopic ph