胰岛素强化基础餐时剂量调整时间疗效对照的研究.docVIP

胰岛素强化基础餐时剂量调整时间疗效对照的研究 　　[摘要] 目的 对照研究胰岛素强化基础餐时剂量调整时间对临床疗效的影响。 方法 选择2016年5月―2017年5月期间在该院行胰岛素强化治疗的190例2型糖尿病患者，随机分为对照组和观察组。两组均采用胰岛素强化基础餐时方案治疗，观察组执行临时医嘱（每餐调整剂量），对照组执行长期医嘱（2～3 d调整1次），观察两组患者治疗后血糖指标变化及不良反应情况。 结果 治疗1周后、2周后，观察组空腹和餐后2 h血糖指标均显著低于对照组，组间差异有统计学意义（P0.05）。观察组低血糖反应发生率（8.42%，8/95）显著低于对照组（17.89%，17/95），组间差异有统计学意义（P0.05）。 结论 胰岛素强化基础餐时方案临时医嘱疗效优于长期医嘱，可有效提升血糖控制效果，降低低血糖发生率。 　　[关键词] 胰岛素强化餐时基础方案；临时医嘱；长期医嘱；对照研究 　　[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062（2017）11（b）-0062-02 　　[Abstract] Objective To compare and research the curative effect of insulin intensive basal-bolus dosage adjustment time. Methods 190 cases of type 2 diabetes patients for insulin intensive therapy in our hospital from May 2016 to May 2017 were selected and randomly divided into two groups， both groups used the insulin intensive basal-bolus therapy， while the observation group conducted the temporary doctor’s signs （adjusting dosage each dinner）， while the control group conducted the long-term doctors’ signs （adjusting the dosage every two to three days）， and the changes of blood glucose and adverse reactions after treatment of the two groups were observed. Results After 1 week and 2 weeks， the fasting and postprandial 2 h blood glucose indicators in the observation group were obviously lower than those in the control group， and the differences were obvious（P0.05）， and the incidence rate of hypoglycemia reactions in the observation group was obviously lower than that in the control group[（8.42%， 8/95） vs （17.89%， 17/95）]， and the differences between groups were obvious（P0.05）. Conclusion The curative effect of temporary doctors’ signs of insulin intensive basal-bolus plan is better than that of long-term doctors’ signs， which can effectively improve the blood glucose control effect and reduce the incidence rate of hypoglycemia. 　　[Key words] Insulin intensive basal-bolus plan； Temporary doctors’ signs； Long-term doctors’ signs； Research on comparison 　　胰?u素强化治疗是一种强化血糖控制的胰岛素治疗模式，在饮食控制和运动疗法的基础上，通过每日多