贝那普利联合中成药治疗糖尿病肾病的的疗效观察.docVIP

贝那普利联合中成药治疗糖尿病肾病的的疗效观察 　　摘要：目的：探讨贝那普利联合中成药治疗糖尿病肾病临床疗效与安全性。方法将310例糖尿病肾病患者随机分为观察组与对照组，每组各155例。在糖尿病肾病常规治疗的基础上，对照组加用盐酸贝那普利，观察组在对照组的基础上，予以金芪降糖片，连续治疗12周，观察两组患者的临床总有效率与实验室指标。结果：观察组与对照组的总有效率分别为88.4%、67.7%，两组比较，具有显著性差异（χ2=19.29，P＜0.01）。治疗后两组患者的24 hUMA、HbA1c、SBP、DBP均较治疗前明显下降（P＜0.05，或P＜0.01）；治疗后，观察组24 hUMA、TC、TG、HbA1c、BUN、Cr的下降幅度优于对照组，差异具有统计学意义（P＜0.05）。结论：贝那普利联合中成药治疗糖尿病肾病，具有较高的临床有效率，明显降低尿微量白蛋白，改善患者的临床症状和相关的实验室指标，且未见明显的不良反应，比单用西药疗效显著，值得临床推广应用。 　　关键词：糖尿病肾病；消渴；水肿；金芪降糖片；贝那普利 　　中图分类号：R587.1文献标识码：B文章编号：1673-7717(2012)03-0655-03 　　 　　Effects of Benazepril Combined with Chinese Medicine in Treatment of Diabetic Nephropathy 　　 　　LU Zhong?min, BU Shuang?yan 　　(Dongyang Peoples Hospital, Dongyang 322100,Zhejiang,China) 　　 　　Abstract:Objective: To investigate the effects and safety of benazepril combined with Chinese medicine in treatment of diabetic nephropathy. Methods: 310 cases with diabetic nephropathy were randomly divided into observation group and control group, 155 cases in each group. On the basis of routine treatment, the control group plus benazepril hydrochloride, the observation group on the basis of the control group, be treated with Jinqi Jiangtang tablet, for 12 continuous weeks, total clinical efficiency and laboratory indexes were observed. Results in the observation group and the control group in the total efficiency were respectively 88?4% and 67.7%, with significant difference (χ2=19.29, P0.01). After treatment, in two groups 24 hUMA, HbA1c, SBP, DBP were significantly decreased compared with those before treatment (P0.05, P0.01); after the treatment, in the observation group, 24 hUMA, TC, TG, HbA1c, BUN, Cr amplitude decreased than those in the control group, the difference was statistically significant (P0.05). Conclusion: Benazepril combined with Chinese medicine in treatment of diabetic nephropathy, has high clinical efficiency, can reduce urinary albumin, improve clinical symptoms and laboratory indexes, and has no obvious adverse reaction, and is mor