贝那普利联合美托洛尔治疗中青年单纯舒张期高血压的的疗效观察.docVIP

贝那普利联合美托洛尔治疗中青年单纯舒张期高血压的的疗效观察 　　[摘要] 目的 观察贝那普利联合小剂量美托洛尔治疗中青年单纯舒张期高血压的疗效及安全性。 方法 选择2013年2月～2015年2月在我院内科门诊就诊的86例中青年单纯舒张期高血压患者，将其纳入门诊高血压管理并随机分为观察组（43例）和对照组（43例）。对照组予贝那普利治疗，观察组予贝那普利联合美托洛尔治疗，疗程均为2个月，观察两组的临床疗效及安全性。 结果 治疗两个月后，观察组总有效率93.02%，对照组总有效率81.39%，观察组总有效率高于对照组，差异有统计学意义（P0.05）；两组患者不良反应较轻，所有患者均能耐受，未因不良反应而停止治疗。 结论 贝那普利联合美托洛尔治疗中青年单纯舒张期高血压疗效确切，无明显不良反应。 　　[关键词] 单纯舒张期高血压；贝那普利；美托洛尔；中青年 　　[中图分类号] R544.1 [文献标识码] B [文章编号] 1673-9701（2016）25-0096-03 　　Observation on the efficacy of benazepril and metoprolol in the treatment of isolated diastolic hypertension in youth 　　MA Jianghua1 ZHANG Xiaoli1 WANG Zhuo2 DONG Mingyue1 FANG Fang1 TAN Xiaoli1 　　1.Qinghe Clinic of the PLA Rocket Force General Hospital，Beijing 100085，China； 2.Clinic of the PLA 96819 Arny， Beijing 100015， China 　　[Abstract] Objective To observe the efficacy and the safety of benazepril and a small dose of metoprolol in the treatment of isolated diastolic hypertension in youth. Methods 86 youth patients with isolated diastolic hypertension in our hospital were randomly divided into observation group（n=43） and control group（n=43） from February 2013 to February 2015. The control group was treated with benazepril， and the observation group was treated with benazepril and metoprolol. 2 months later， the efficacy and safety of treatment was evaluated. Results The total effective rate of the observation group was 93.02%， the total effective rate of the control group was 81.39%. The total effective rate of the observation group was higher than that of the control group（P0.05）. The adverse reactions of the two groups were mild， all patients were able to tolerate， and did not stop treatment because of adverse reactions. Conclusion Benazepril and metoprolol in the treatment of isolated diastolic hypertension in youth has obvious effect and without significant adverse reaction. 　　[Key words] Isolated diastolic hypertension（IDH）；Benazepril；Metoprolol；Youth 　　随着经济快速发展和生活节奏的不断加快，高血压在中青年人群中发病率逐年增加，早期多表现为以舒张压升高为特点，随着病程的发展