贝那普利联合卡维地洛治疗原发性高血压患者临床的的疗效观察.docVIP

贝那普利联合卡维地洛治疗原发性高血压患者临床的的疗效观察 　　摘要：目的观察贝那普利联合卡维地洛治疗原发性高血压患者的疗效及对心肌肥厚的影响。方法将90例原发性高血压患者随机分为观察组和对照组, 观察组用贝那普利加卡维地洛；对照组单用贝那普利。两组疗程均为12月。治疗期间监测血压、空腹血糖、血脂、血钾、血尿酸、尿素氮和肌酐等,观察药物的安全性。结果观察组50例，有效率92%(46/50),血浆血管紧张素Ⅱ（AngⅡ）和醛固酮（Ald）水平明显下降(P0.05)；两组治疗前后空腹血糖、血脂、肾功能及电解质无显著变化(P0.05)。结论贝那普利联合卡维地洛治疗原发性高血压患者可安全有效降压,逆转心肌肥厚；改善左室功能。且耐受性好,副作用少,而且对代谢无明显的影响，值得在临床上推广应用。 　　关键词：贝那普利；卡维地洛；高血压 　　Effect of Combine Reatment of Benazepril and Carvedilol in Patients with Essential Hypertension 　　GUI Shu-jie,WANG Jiao-long 　　(Department of Cardiology,General Hospital of Dongfang Group,Huainan 232001,Anhui,China) 　　Abstract：ObjectiveTo approachthe curative effect of combine reatment of benazepril and carvedilol and its impact on myocardial hypertrophy in patients with essential hypertension．MethodsNinety hypertensive patients were randomly designed to observation group and control group, the observation group (n=50),which were treated with benazepril and carvedilol, and the control group(n=40),which received treatment with only benazepril. the treating course was 12 months for both groups, Blood pressure、blood glucose、blood fat、serum potassium、blood uricacid、urea nitrogen and creatinine and the safety of drugs were examined． ResultsAfter treatment the response rate was 92% in the observation group(n=50), the Serum concentrations of Anglland Ald were significantly decreased(P0.05 )；Fasting blood-glucose, blood fat, renal function and electrolytes had no significant change before and after treatment in different groups.ConclusionBenazepril combined with carvedilol is capable of Safe and effective antihypertension，reversing left ventricular hypertrophy and improving cardiac function, it had well tolerance，lower adverse reactions and no perceptible effect on metabolism ,wich should be widely spreaded in clinics should be widely spreaded in clinics. 　　Key words：Benazepril; Carvedilol ;Essential hypertension 　　高血压病是体循环动脉压增高为主要表现的临床综合征，左心室肥厚(LVH)是高血压患者最常见的并发症，是具有独立作用的心血管疾病的危险因素[1]。因此，高血压病的临床治疗不仅在于降低患