慢性阻塞性肺病合并心力衰竭时血浆B型尿钠肽变化剖析.docVIP

慢性阻塞性肺病合并心力衰竭时血浆B型尿钠肽变化剖析 　　doi：10.3969/j.issn.1007-614x.2014.2.65 　　摘 要 目的：探讨慢性阻塞性肺病合并心力衰竭时血浆B型尿钠肽的水平及临床意义。方法：选择慢性阻塞性肺病患者120例，所有入选者按照美国纽约心脏病协会（NYHA）分级方案将心功能分为Ⅰ～Ⅳ级，同时经2名高年资主治医师确认。采用免疫荧光法测定B型尿钠肽水平，并进行比较。结果：重度心力衰竭组B型尿钠肽水平显著高于轻中度心力衰竭组，心力衰竭与B型尿钠肽水平有较强的正相关性。结论：慢性阻塞性肺病合并心力衰竭时血浆B型尿钠肽水平增高，B型尿钠肽增高的程度与心力衰竭有较强的正相关。 　　关键词 慢性阻塞性肺病 心力衰竭 B型尿钠肽 　　To analysis the changes of plasma B-type natriuretic peptide in chronic obstructive pulmonary disease with heart failure 　　Deng Xiangyun，Zhang Hongguo 　　Respiratory of the First Peoples Hospital of Jia Yuguan City in Gansu Province， 735100 　　Abstract Objective：To explore the changes and clinical significance of plasma B type natriuretic peptide in chronic obstructive pulmonary disease associated with heart failure.Methods：We selected 120 cases of patients with chronic obstructive pulmonary disease.All the patients heart function was divided into Ⅰ～Ⅳ grade according to USA New York Heart Association（NYHA） classification scheme and confirmed by 2 senior doctors at the same time.We used immunofluorescence method for the determination of B type natriuretic peptide levels and compared them.Results：The B type natriuretic peptide levels of severe heart failure group were significantly higher than the mild to moderate heart failure group and there was a positive correlation between the heart failure and B type natriuretic peptide levels.Conclusion：Plasma B type natriuretic peptide levels were increased in the chronic obstructive pulmonary disease associated with heart failure.There was a positive correlation between the heart failure and B type natriuretic peptide levels. 　　Key words Chronic obstructive pulmonary disease；Heart failure；B type natriuretic peptide 　　资料与方法 　　2011年10月-2013年4月收治慢性阻塞性肺病患者120例，男78例，女42例，年龄54～84岁，平均61.4岁，诊断符合中华医学会呼吸病学分会慢性阻塞性肺疾病诊断标准。 　　方法：所有人选者按照美国纽约心脏病协会（NYHA）分级方案将心功能分为Ⅰ～Ⅳ级，同时用南京普朗医用设备有限公司FIA 8000系列免疫定量分析仪进行B型尿钠肽检测。 　　统计学处理：采用SPSS12.0统计软件进行统计学分析，所有计量资料均用（x±s）表示，多组比较采用方差分析，先进行方差齐性检验，方差齐时各组间两两比较采用q检验，P0.05认为具有统计