丹参注射液对慢性胰腺炎治疗作用-普外科学专业论文.docx

山西医科大学硕士学位论文 山西医科大学硕士学位论文 IV IV Intraductal injection of 2% TNBS immediately found congestion and swelling of pancreatic tissue, rats were killed after 4 weeks, remove the pancreas, the pancreas can be seen significantly smaller size, texture, hardening, and the blurred boundaries with the surrounding tissue, high-power microscope, interstitial inflammatory cell infiltration of pancreas, a large number of fibrous tissue hyperplasia, dense collagen and fibroblasts to islet cell division; pancreatic acinar foam cell loss and some vacuolar degeneration, shrunken cell bodies calcification, pancreatic duct hyperplasia expansion of perivascular fibrosis, perivascular and interlobular and intralobular pancreatic fibrosis with inflammatory cell infiltration. Salvia also occurred in the intervention group, pancreatic fibrosis, but the SM group than in model group intervention significantly reduced fibrosis, and with increasing doses of Danshen injection of pancreatic fibrosis were gradually reduce the trend. The five rat pancreatic tissue biopsy for fibrosis score, that score higher than the control group, the intervention group Salvia, a higher degree of fibrosis. ELISA, the test showed that: LN and HA in the intervention group were significantly lower than the control group, and the difference was significant. Conclusions: Danshen injection in rats with chronic pancreatitis and pancreatic tissue against fibrosis. By Danshen injection on the treatment of chronic pancreatitis and fibrosis, can be obvious from the pathological changes observed in pancreatic fibrosis of chronic pancreatitis decreased, while chronic pancreatitis serum LN and HA were significantly lower Key Words：Danshen injection; pancreatic fibrosis; laminin; hyaluronic acid V V 中英文缩写词对照表 缩 写 全 称 中 文 LN Laminin 层粘连蛋白 HA Hyaturonic acid 透明质酸 TNBS Trinitro-benzene-sulfonic acid 三硝基苯磺酸 ELISA Enzyme linked immunosorbent assay 酶联免疫分析法 TanshinongⅠ TanshinongⅠ 丹参酮Ⅰ Tanshinong Ⅱ Tanshino