超声造影技术评价冠心病患者颈动脉粥样硬化斑块新生血管-影像医学与核医学专业论文.docxVIP

华中科技大学博士学位论文 华 中 科 技 大 学 博 士 学 位 论 文 PAGE 10 PAGE 10 ABSTRACT Evaluation of carotid plaque neovascularization in patients with coronary heart disease using contrast-enhanced ultrasound imaging PART Ⅰ Evaluation of the relationship between carotid plaque neovascularization and coronary heart disease by contrast-enhanced ultrasound imaging Objectives Acute coronary syndrome （ACS）are closely associated with coronary vulnerable plaques. Our study was undertaken to evaluate the relationship between carotid plaque neovascularization and coronary heart diseas by contrast-enhanced ultrasound imaging. Methods 40 patients（ 31 males and 9 females, aged 45 ~ 76 years old）with acute coronary syndrome （ACS）and 40 patients （29 males and 11 females, aged 45 ~ 76 years old）with stable coronary artery disease （sCAD）were included in our study, Inclusion criteria were at least 1 carotid atherosclerotic plaque with thickness larger than 2.0mm. Contrast-agent enhancement in the plaque was evaluated by visual interpretation and quantitative analysis. Results The percentage of soft plaque in the acute coronary syndrome group was significantly higher than that in stable coronary artery disease group (P=0.017)． The proportion of contrast-agent enhancement in patients with acute coronary syndrome was significantly than in patients with stable coronary artery disease（P=0.022). The enhanced intensity in the plaque and the ratio of enhanced intensity in the plaque to that in the carotid artery lumen in patients with acute coronary syndrome were significantly larger than those in patients with stable coronary artery disease (P0.001; P=0.026,respectively). Sensitivity and specificity were 74%and 60%, respectively, for enhanced intensity in the plaque and 86% and 67%, respectively, for ratio of enhanced intensity in the plaque to that in the lumen of the carotid artery. Conclusions The subjects with acute coronary syndrome had more intense contrast-agent enhancement than the subjects with s