肝硬化与正常肝脏双重血流量定量对比研究-影像医学与核医学专业论文.docxVIP

汕头大学硕士研究生学位论文 汕头大学硕士研究生学位论文 万方数据 万方数据 I 肝硬化与正常肝脏双重血流量定量对比研究 摘 要 目的：应用双能 CT 的碘定量功能，研究肝硬化与正常肝脏双重血供的差异。 方法：针对临床确诊的 34 例肝硬化组病例进行双能 CT 增强扫描，随机选择上腹部 双能 CT 增强扫描正常肝脏 27 例作为对照组，将两组病例图像传输至工作站，应用能 谱分析软件获得肝脏增强扫描动脉期、门静脉期、延迟期各叶兴趣区的碘基值，并计 算出肝动脉碘分数与门静脉碘含量，再用 SPSS13.0 软件对各项参数进行独立样本 t 检 验。 结果：动脉期肝硬化组和正常肝组之间，各叶碘基值总和相近，差异无统计学意义 （P0.05），但肝硬化组的左外叶动脉期碘基值明显高于正常组，差异具有统计学意义 （P=0.033）。门静脉期肝硬化组和正常组之间，各叶碘基值总和差异有统计学意义 （P=0.039）；肝硬化组门静脉期左内叶和右叶的碘基值明显低于正常组，差异具有统 计学意义（P=0.021，0.001）。肝硬化组延迟期左外叶和尾状叶的碘基值明显高于正常 组，差异有统计学意义（P=0.021，0.031）。肝硬化组左外叶、左内叶及右叶肝动脉碘 分数（arterial iodine fraction, AIF）与正常组比较，差异均有统计学意义（P0.05）；肝 硬化组左外叶、左内叶及右叶的门脉期与动脉期碘含量之差即门静脉碘含量（portal venous iodine concentration, PVIC）与正常组比较，差异均有统计学意义（P0.05）；肝 硬化组左外叶、左内叶及右叶 AIF 均高于正常组，门静脉供血量低于正常组。 结论：肝硬化与正常肝脏两组病例间，肝脏各叶的血供存在明显差异，双能 CT 的碘 定量功能可用于评价肝硬化的血流动力学改变。 关键词：肝硬化；双重血供；能谱成像；血流量；碘定量 汕头大学硕士研究生学位论文 汕头大学硕士研究生学位论文 II Quantitative Contrast of Dual-perfusion Characteristic between Liver Cirrhosis and Healthy Liver Abstract Objective: To explore the differences of dual-perfusion in left lateral lobe, left medial lobe, right lobe and caudate lobe between healthy liver and liver cirrhosis by using the iodimetric function of dual-energy CT. Methods: 34 cases with liver cirrhosis and 27 cases without hepatic diseases underwent contrast-enhanced upper abdomen dual-energy CT scanning in GSI mode. The raw data were transferred to the workstation. Regions of interest (ROI) were selected, and the iodine concentration in arterial phase, portal venous phase and delay phase in different hepatic lobes, the arterial iodine fraction（AIF）and the portal venous iodine concentration (PVIC) in two groups were calculated. The differences of these parameters were detected by independent sample t test. Results: The sum of iodine concentration in all the lobes during arterial phase in the study group had no statistical difference with the control group（P0.05）; The iodine concentration in the left lateral lobe during arterial phase in the study group was significantly higher than t