肺动脉高压致左心功能不全的相关性研究-内科学(心血管内科学)专业论文.docxVIP

上海交通大学硕士研究生学位论文 上海交通大学硕士研究生学位论文 PAGE PAGE 12 缔组织疾病为影响患者心功能恶化的独立危险因素。 2）经吸入性伊洛前列素治疗，可有效降低患者肺动脉收缩压及右 室收缩压，改善患者因肺动脉高压而致的左室舒张充盈障碍；延缓肺动 脉高压引起的左心室结构重构，并在一定程度上改善患者的运动耐量。 3）卡维地洛联合选择性肺血管扩张剂治疗肺动脉高压致左心功能 不全，在改善患者左心室结构重构以及患者左心舒张功能上疗效不显著。 【关键词】：肺动脉高压，左心舒张功能不全，吸入性伊洛前列素，卡维 地洛 The Corresponding Study On The Dysfunction Of Left Heart Ventricular In Patients With Pulmonary Arterial Hypertension Abstract Objective: The purpose of the study is to investigate whether or not there are any changes on left ventricular diastolic function in patients with PAH. The benefit of inhaled iloprost in patients with PAH is estimated. The conjoint thrapy of carvedilol and selective vasodilator of pulmonary circulation for PAH with left heart dysfunction is also investigated. Methods: We compile clinic and outcome data on 58 patients in our hospital from Jan 2005 to May 2008,half of who are with PAH,the others are normal subjects.With the help of transthoracic echocardiography,left atrial diameter,left ventricular end-diastolic dimension, interventricular septal thickness,left ventricular end-systolic dimension,mitral flow velocity and left ventricular ejection fraction were measured. Furthermore,we compile clinic and outcome data on 3 patients in our hospital from April 2007 to November 2008.With the help of transthoracic echocardiography, left ventricular end-diastolic dimension, interventricular septal thickness, mitral flow velocity and left ventricular ejection fraction were measured. Pulmonary arterial systolic pressure, right ventricular pressure, pulmonary vascular resistence and cardial output were measured by Swan-Ganz catheter.6-minute walk test was also tested. We also compile clinic and outcome data on 4 patients in our hospital from Jan 2005 to May 2008,half of who are with carvedilol,the others are without it.With the help of transthoracic echocardiography,left ventricular end-diastolic dimension, interventricular septal thickness,left ventricular end-systolic dimension,mitral flow v