血管生成因子和耐药相关基因在胃癌中的表达与意义.pdfVIP

difference between GC and IM 、Dys and IM of bFGF(P0.05), but no significant difference between GC and Dys(P0.05);significant difference between GC and IM of P-gp(P0.05), but no significant difference between GC and Dys 、Dys and IM(P0.05); significant difference between GC and Dys 、IM, Dys and IM of MRP-1(P0.05). 2 MRP-1mRNA of gastric carcinoma is positively higher than other groups （χ 2=12.436 ），there a significant difference between them(P0.01). 3 Apoptosis index(AI) indicates a decreasing tendency in gastric carcinogensis, GC group significantly lower than other groups(P0.01). Expression of MRP-1 is related positively with that of MRP-1mRNA (r=0.598 ，P0.05). 4 There were positive corelation between VEGF and P-gp、VEGF and MRP-1、 bFGF and P-gp、bFGF and MRP-1. Furthermore, expressions of VEGF 、bFGF 、P-gp、 MRP-1 all closely correlated with lymphnode metastasis and vascular invasion(P0.05). Expressions of VEGF 、P-gp 、MRP-1 in early GC markedly lower than that in advanced GC(P0.05).In addition,AI was also related with the clinical stages of gastric carcinoma(P0.05). Conclusions: 1 Expressions of VEGF 、bFGF 、P-gp、MRP-1 show a gradually increasing tendency in gastric carcinogensis, expressions of VEGF 、bFGF are positive with P-gp、MRP-1, VEGF 、bFGF would promote expressions of P-gp 、MRP-1. 2 VEGF、bFGF 、P-gp 、MRP-1 inhibit cell apoptosis. 3 Expression levels of VEGF 、bFGF 、P-gp 、MRP-1 and AI may be regarded as a marker for evaluating malignant degree , lymphnode metastasis and prognosis of Key words: gastric carcinoma; VEGF ; bFGF; P-gp; MRP-1; cell apoptosis Postgraduate:Jia-tai Xie Supervisor :Ming-liang