高强度聚焦超声治疗异常子宫出血分析-临床医学专业论文.docxVIP

Ab Abstract IV IV ABSTRACT Objective: Apply high intensity focused ultrasound (HIFU) in treatment of abnormal uterine bleeding (AUB), observe pathological changes of endometrium and PR, expression changes of ER before and after treatment, discuss its effect mechanism and prevent future relapse. By follow-up observations and comparison with high intensity focused ultrasound (HIFU) in treatment of abnormal uterine bleeding (AUB) and the clinical effect of transcervical resection of endometrium, assess its safety and efficacy of treatment. Method: chose 42 AUB patients who had no fertility requirements and voluntarily accepted to treat AUB by HIFU, 26 patients accepted transcervical resection of endometrium. HIFU treatment group applied HIFU to function layer , base layer, and even under 3 mm of muscle layer 3 mm for thermal radiation,divided into 2 ~ 3 treatment level, 1 /d. The two groups should do follow up observation for 12 months after treatment. Made a comparison of the total effect between HIFU treatment group and transcervical resection of endometrium group, including menstrual blood volume,Hb and the differences of color doppler ultrasonic examination of endometrium before and after treatment. And did diagnostic curettage within a month of before treatment and a year of after treatment to HIFU treatment group, took endometrial tissue to stain with HE to observe its changes of histomorphology and pathological type, tested ER, PR expression level by immunohistochemistry staining at the same time. Used SPSS 18.0 statistical software to analyze the data. The difference was statistically significant with P0.05. Results: 1, Curative effect comparison of DUB treated by HIFU and transcervical resection of endometrium: 1.1 It showed the total effective rate of HIFU was 93% (39/42) and total effective rate of electrocision group was 88% (23/26) by observing the curative effect after posttreatment 12 months. HIFU treatment group has more significant effect. 1.2 the chan