自制中药膏与哈西奈德乳膏治疗外阴上皮内非瘤样病变的疗效观察.docVIP

PAGE PAGE 5 自制中药膏与哈西奈德乳膏治疗外阴上皮内非瘤样病变的疗效观察 杨盛红 梁志刚 肖雁冰★ [摘　要] 目的 探讨两种自制中药膏与哈西奈德乳膏治疗外阴上皮内非瘤样病变的临床效果。方法 将167例外阴上皮内非瘤样病变病人随机分成A、B两组；A组（134例）用自制中药膏治疗，B组（43例）用哈西奈德乳膏治疗，观察、分析两组病人治疗前后症状、体征、组织病理变化以及A组部分病人治疗前后EGFR的表达。结果 A组病人治愈率、有效率和无效率分别为：75.4%、19.8%和4.8%。B组分别为：4.9%、61.0%和34.5%，差异具有显著性（P＜0.001）；A组部分治愈病人治疗前、后EGFR值分别为：0.110±0.018和0.086±0.009（P＜0.001）。结论　两种自制中药膏对外阴上皮内非瘤样病变具有良好的治疗效果和安全性，值得进一步研究。 [关键词] 　中药膏；外阴上皮内非瘤样病变；疗效 Therapeutic Effects of Treatment Leukoplakia Vulvae by Using Self-Made Chinese Ointment and Halcinonide Cream，A Clinic Study YANG Sheng-hong, LIANG zhigang＊, XIAO Yan-bing Department of obstetrics and gynecology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China 作者单位：563003 遵义,贵州省遵义医学院附属医院妇科。★通迅作者：E-mail: HYPERLINK mailto:arronxiaoice@ arronxiaoice@; Tel: 08528608162 [Abstract] Objective: To explore the therapeutic effects of treatment leukoplakia vulvae (LV) by using two kind of self-made chinese ointment (SMCO) and Halcinonide cream (HC). Methods: 167 cases of LV patients were randomly divided into two groups, group A and group B with 134 cases and 43 cases respectively. Patients in group A were treated with SMCO while patients in group B were treated by HC. The symptoms and signs as well as pathological changes both in two groups pre- and post treatment were observed and analysis. Furthermore, the expression of EGFR of some patients in group A before and after treatment also were detected by the method of Streptomycin avidin-peroxidase. Results：The rate of cure, efficiency and inefficiency were75.4%, 19.8% and 4.8% in group A and 4.9%, 61.0% and 34.5% in group respectively, the difference was significant (P 0.05). 作者单位：563003 遵义,贵州省遵义医学院附属医院妇科。 ★通迅作者：E-mail: HYPERLINK mailto:arronxiaoice@ arronxiaoice@; Tel: 08528608162 [Key words] Chinese ointment, Matrix, Leukoplakia Vulvae, Therapeutic effects 外阴上皮内非瘤样病变是妇科常见疾病，主要包括：外阴鳞状上皮增生（增生型）、外阴硬化性苔癣（苔癣型）和外阴硬化性苔癣合并鳞状上皮增生（混合型），由于确切的病因不明，迄今为止，仍缺乏公认的治疗方法。作者通过长期研究，总结出两种中草药膏治疗该病，取得了良好的治疗效果[1]，并获两项国家发明专