Drug Delivery System药物投递系统.ppt

Toxin Moiety Ann. Rev. Immunol. 1996. 14:49–71 医学资料 * Linkers 医学资料 * Factors affecting the potency of an IT 医学资料 * Clinical trials 医学资料 * Conclusions 医学资料 * References 医学资料 * Overview of Worldwide Drug Market 主讲:萧宏展 医学资料 * Worldwide drug market sales 医学资料 * 2003全球各区域药品市场销售额 资料来源:IMS Health Total sales: around 5000亿美金 医学资料 * 全球十大药物销售 医学资料 * Drug delivery system market 2002年 worldwide sales: $41.1 billion 2007年(e) worldwide sales: $66 billion 资料来源:Front Line Strategic Consulting, Inc. 医学资料 * Drug delivery system Drug delivery system Oral controlled release Polymer Pulmonary Transdermal Transmucosal others 医学资料 * Oral controlled release Sustained release or extended release drug Compound is less susceptible to gastric degradation Company:Elan Corp. and JJ Alza Product:Nexium (R) Esomeprazole ($3302 millino) 、Losec/Prilosec for treatment of gastric ulcer . 医学资料 * Polymer A method of drug delivery in which a therapeutic is encapsulated in polymeric matrix and is slowly released at the site of action via diffusion and surface erosion. Inactive in the bloodstream Company: JJ Alza 、Atrix Product: PEG-Intron (pegylated interferon) for treatment of chronic hepatitis C 医学资料 * Pulmonary Improve patient compliance associated with the relative comfort and convenience of inhalers. Company: GlaxoSmithKline、Aerogen,Inc.、Nektar therapeutics Product: Aerodose? Insulin Inhaler、 Seretide/Advair for treatment of asthma 医学资料 * Transdermal Enable the passage of drug molecules across skin Lower dosing of medications result in few adverse side effects Company: JJ Alza 、Noven Pharmaceutical Product: Catapres-TTS? (clonidine) for treatment of hypertension 、 NicoDerm? CQ? (nicotine) and Clear NicoDerm? CQ? 医学资料 * Transmucosal Drug is introduced to the body across a mucous membrane which allows for the avoidance of the gastrointestinal tract and first pass liver metabolism and consequently allows the therapeutic to directly enter into circulation. Company: Nastech Ph