响应面法优化十味盆安颗粒真空带式干燥工艺研究-天津中草药杂志社.PDF

·1914 · 中草药 Chinese Traditional and Herbal Drugs 第 46 卷 第 13 期 2015 年 7 月 响应面法优化十味盆安颗粒真空带式干燥工艺研究 刘长龙，李云霄，钱 俊，吴 云，萧 伟* 1. 江苏康缘药业股份有限公司，江苏 连云港 222001 2. 中药制药过程新技术国家重点实验室，江苏 连云港 222001 摘 要：目的 优选十味盆安颗粒真空带式干燥的最佳工艺。方法 在单因素考察的基础上，选择进料速度、加热温度、干 燥时间 3 个主要因素，以干膏含水率、虎杖苷和芍药苷转移率的综合评分响应值，采用响应面法对十味盆安颗粒真空带式干 燥工艺进行优选。结果 优选的最佳工艺条件为进料速度 1.6 kg/h，加热温度 105 ℃，干燥时间 104 min，此时干膏平均含 水率为 2.80% ，虎杖苷平均转移率为 92.55%，芍药苷平均转移率为 94.77%，综合评分为 95.35，RSD 为 0.42% 。结论 采用 响应面法优选的工艺稳定可行，有效成分转移率高，可指导产业化生产。 关键词：响应面法；真空带式干燥；十味盆安颗粒；虎杖苷；芍药苷 中图分类号：R283.6 文献标志码：A 文章编号：0253 - 2670(2015)13 - 1914 - 06 DOI: 10.7501/j.issn.0253-2670.2015.13.010 Optimization for vacuum belt drying process of Shiwei Penan Granule by using response surface methodology LIU Chang-long, LI Yun-xiao, QIAN Jun, WU Yun, XIAO Wei 1. Jiangsu Kanion Parmaceutical Co., Ltd., Lianyungang 222001, China 2. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China Abstract: Objective To optimize the vacuum belt drying process of Shiwei Penan Granules. Methods On the base of single factor experiments, feeding rate, heating temperature, and drying time were selected as the main factors, with composite score of moisture content of dry paste, rates of polydatin and paeoniflorin transfer as the response values, response surface methodology was used to optimize the vacuum belt drying process. Results Optimal parameters were as follows: The feeding rate was 1.6 kg/h, heating temperatures was 105 ℃, drying time was 104 min; Under these conditions, moisture content of dry extract was 2.80% on average, the transfer rate of polydatin was 92.55%, and the transfer rate of paeoniflorin was 94.77% on average, the composite score was 95.35 on average, RSD = 0.42%. Conclusion The condition optimized by using response surface methodology is stable and reasonable, which could guide industrial pr