局部植入治疗骨与关节结核药物缓释体的制备与特性研究-外科学专业论文.docxVIP

第二军 第二军医大学博士学位论文 局部植 局部植入治疗骨与关节结核药物缓释体的制备与特性研究 - - PAGE 4 - - - PAGE 5 - 结论：本实验通过物理的方法将 BG-MSN 加入复合到 β-TCP 内，形成的复合材 料骨诱导成骨能力肯定，类似于 β-TCP，说明其作为抗结核药物的缓释载体，在骨与 关节结核行病灶清理术时，可以作为骨充填支架材料，具有良好的充填和诱导成骨能 力。 关键词：β-磷酸三钙，介孔二氧化硅，生物玻璃胶，异烟肼，利福平，骨与关节结 核，缓释 Abstract In recent ten years, with a high uptrend of TB (tuberculosis) there were about 20 million patients suffering from TB all over the world. And there were 5 million TB patients now in china, ranking the second in the world. The patients who had bone and articular tuberculosis accounting for 1~2% of all TB patients in our country usually had to face up to the therapeutic schemes including an anti-tubercular drugs regime or/and a surgery treatment. A bone TB focus debride was often recommended by the special surgeon and accepted by those patients whose bone and joints had been destroyed badly and normal physiological function had been impaired partially or wholly. With the development of orthopedic inner fixation materials, there was prone to perform a focus debride and bone defect reconstructive surgery as early as the special surgeon could. One question was, however, that it was very difficult to reconstruct the residual cavity for much defect of removed disable bone especially around the spine and big joints after the focus debride. Another question was the recurrence of the local residual Mycobacterium tuberculosis which would lead to the failure of implanted autologous or allograft bone or bone materials. Meanwhile, it was recommended and required for those patients to use anti-tuberculous drugs therapy systemicly at least for 6~9 months after the treatment of an adequate surgical debridement, which would result in bad compliance and a lot of side effects. A proper solution to the difficult problem was maybe to implant some controlled release antitubercular drugs into the residual cave. Those controlled release antitubercular drugs were expected to adhered to scaffolds of bone substitute materials which would bring for