子宫内膜异位症患者血清MMP-9TIMP-1表达及-中国现代应用药学.PDF

子宫内膜异位症患者血清MMP-9 、TIMP-1 表达及红藤方的干预研究 黄晓燕 1 ，楼红英 2 ，黄筱泓 3 ，束兰娣 1 ，戴德英 1(1.上海中医药大学附属曙光医院，上海 201203 ；2.浙江大学医学院附属邵 逸夫医院，杭州 310016 ；3.浙江省湖州市中心医院，浙江 湖州 313000) 摘要：目的 探讨子宫内膜异位症患者采用红藤方治疗的临床疗效及血清 MMP-9 、TIMP-1 及其比值的变化。方法 经 腹腔镜手术确诊为子宫内膜异位症的患者 90 例随机分为 3 组即红藤方组、米非司酮组和对照组，观察 3 组的临床疗效， 并于术前及药物治疗 3 月后分别测定血清 MMP-9 和 TIMP-1 水平。结果 与对照组比较，红藤方组和米非司酮组总有效 率明显提高(P0.05) ，且后 2 者治疗后 MMP-9 水平明显降低，TIMP-1 水平显著提高，与前者相比差异均具有统计学意 义(P0.01) 。MMP-9/TIMP-1 比值 3 组治疗前后均显著降低，且治疗后红藤方组和米非司酮组与对照组比较下降更明显， 差异具有统计学意义(P0.05) 。结论 红藤方可能通过调节 MMP-9 /TIMP-1 的平衡而纠正盆腔内环境，有效改善子宫内 膜异位症患者的临床症状。 关键词：子宫内膜异位症；红藤方；MMP-9 ；TIMP-1 中图分类号：R285.6 文献标志码：A 文章编号：1007-7693(2013)01-0194-04 Study on Serum MMP-9 and TIMP-1 Levels in Endometriosis by Caulis Sargentodoxae Formula 1 2 3 1 1 HUANG Xiaoyan , LOU Hongying , HUANG Xiaohong , SHU Landi , DAI Deying (1.Shuguang Hospital, Shanghai Traditional Chinese Medicine University, Shanghai 201203, China; 2.Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; 3.Zhejiang Huzhou Hospital, Huzhou 313000, China) ABSTRACT: OBJECTIVE To study the clinical value of laparoscopic operation combined with Caulis Sargentodoxae Formula on endometriosis. METHODS Ninety cases diagnosed endometriosis who were underwent laparoscopic operations were divided into three groups at random, 30 cases were treated with Caulis Sargentodoxae Formula as the Caulis Sargentodoxae Formula group, 30 cases were treated with mifepristone as the mifepristone group, the other 30 cases as the control group. RESULTS The total effective rate was significantly higher in the Caulis Sargentodoxae Formula group and in the mifepristone group than that of in the control group (P0.05). After treatment, serum MMP-9 level was significant lower and serum TIMP-1 level was