肌注维生素K1致湿疹型皮肤反应及文献回顾-中国药事.PDF

中国药事 2018年10月 第32卷 第10期 1449 肌注维生素K致湿疹型皮肤反应及文献回顾 1 甘美婵，秦秀英，阮炎鹏，甄乐锋 （江门市人民医院，江门 529000） 摘要 目的：总结维生素K 注射液肌肉注射后引起皮肤反应的临床特征及治疗方法。方法：对1例产妇肌 1 注维生素K 致湿疹型皮肤反应进行报道，并对相关文献报道的情况进行回顾性汇总分析。结果：维生素 1 K 注射液导致的皮肤反应为非Ig E介导的Ⅳ型过敏反应，主要由增溶剂聚山梨酯80所引起，抗过敏治疗效 1 果不显著。结论：应严格掌握用药的适应证，加强用药监测，提高用药警惕性，保障患者用药安全。 关键词： 维生素 K ；肌肉注射；过敏反应 1 R758.25 A 1002-7777(2018)10-1449-04 中图分类号： 文献标识码： 文章编号： doi:10.16153/j.1002-7777.2018.10.023 Eczematous Skin Reaction Caused by Intramuscular Injection of Vitamin K1 and Literature Review Gan Meichan, Qin Xiuying, Ruan Yanpeng, Zhen Lefeng (The People’s Hospital of Jiangmen, Jiangmen 529000, China) Abstract Objective: To summarize the clinical characteristics and the treatment of skin reaction caused by intramuscular injection of vitamin K . Methods: A puerperal case of eczematous skin reaction caused by 1 intramuscular injection of vitamin K was reported and the relevant literature was retrospectively analyzed. 1 Results: The skin reaction caused by intramuscular injection of vitamin K was non-IgE-mediated type IV 1 anaphylactic reaction, which was incurred by the solubilizer Polysorbate 80. Therefore, the effect of anti- anaphylactic treatment was not significant. Conclusion: The physicians should strictly control indications of the drug use, strengthen the monitoring of medication, increase the vigilance of medication and ensure patients the medication safety. Keywords: vitamin K ; intramuscular injection; anaphylactic reaction 1 维生素K是肝脏合成凝血酶原（凝血因子Ⅱ）