基于光电容积脉搏波的舒张期衰减时间常数的研究-生物医学工程专业论文.docxVIP

浙江大学硕士学位论文 浙江大学硕士学位论文 摘要 摘 要 光电容积脉搏波(PPG)蕴含着丰富的心血管系统的生理病理信息。目前研究主要基于 没有实际生理意义的幅度信息，却忽略了反映全身血管特征的形态学参数．衰减时间常数 作为常用的形态学参数，可用来评估动脉粥样硬化等心血管疾病．由于现有衰减时间常数 的估算方法或需要流量和(或)压力信息，或容易失效，并不完全适用于PPG． 因此，本论文的研究目标是基于PPG的形态提出一种新的估算衰减时间常数的非迭 代算法(Non．iterative shape method，NSM)，主要工作如下： l、通过仿真方法对比研究单腔及双腔模型的特点，得出双弹性腔模型复杂度高、实 用性差的缺点，因此采用单弹性腔模型来描述PPG。 2、仿真验证衰减时间常数与PPG形态的相关性．分析比较了现有衰减时间常数估算 方法，得出只有拟合法适用于PPG，由于容易迭代失败，鲁棒性不高，并不是最优算法。 3、提出NSM法．从PPG形态中提取出一个名为下降支面积差比(ADR)的参数， 与衰减时间常数建立数学关系，借助分段线性插值估算衰减时间常数． 4、仿真和临床验证NSM法的准确及可行性．仿真结果的误差小于±3％．临床实验 表明，与拟合法相比，NSM法效率提高近100倍，PPG曲线复原度几乎无差别． NSM法基于PPG的形态，不需要对信号进行预校准或者归一化，优于现有其他算法． 关键词：光电容积脉搏波，弹性腔模型，衰减时间常数，下降支面积差比、仿真 Ⅱ 浙江大学硕士学位论文Abstract 浙江大学硕士学位论文 Abstract Tlle photoplethysmogram of a pulse wave(PPG)contains abundant pathophysiological in- formation about human cardiovascular system．Contemporary investigations were almost based on the magnitude with no physiological significance，and overlooked the morphological param- eters associated with cardiovascular system．ne decay time constant is a helpful morphological parameter in vascular disease assessment，such as atherosclerosis．However, conventional methods could not achieve a satisfactory estimation for no pressure and／or flow acquisition from PPG，or approach failure easily． Thus，the thesis aims to propose a novel non-iterative method(NSM)for estimating the decay time constant based on the shape of PPG pulse．The main jobs are as follows： l、Choose the one-order Windkessel model to describe PPG for the third-order Windkessel model has great complexity and weak adaptability by simulation study． 2、Approve that the decay time constant depends on the morphology of diastolic PPG pulse based on simulation experiment；Compare the previous estimation methods and concluded that only fitting method appeared feasible，but non-optimal out of the concomitant problem of convergence． 3、Establish a mathematic expression between RC and a novel morphological parameter called the area difference ratio(ADR)from PPG，and estimate