基于功能磁共振成像的面瘫脑功能和效应连接研究-生物医学工程专业论文.docxVIP

摘要摘要 摘要 摘要 功能磁共振成像是研究面瘫康复机理的一个重要工具。目前，研究人员主要 通过功能连接的方法来研究面瘫。功能连接只能间接测量脑区之间的协同性，而 它不能反映脑内信息的动态交互情况。所以，单纯地通过功能连接研究面瘫大脑 是不足的。因此，本文结合功能和效应连接的方法来面瘫脑网络。 本文研究面瘫脑的前扣带回功能连接强度与面瘫康复过程的关系。首先，在 健康被试激活统计图基础上选取双侧前扣带回作为种子点。然后分别计算双侧前 扣带回和全脑的功能连接。最后选取康复时间作为协变量进行协变量分析得到功 能连接强度和疾病的康复过程之间的关系。实验结果显示同侧前扣带回的功能连 接强度在康复过程中逐渐增强，并且连接强度和康复时间呈现正相关关系。本研 究表明前扣带回功能连接在病人康复过程中调节了大脑的功能重组，这一过程对 面瘫的康复起着重要的作用。 为了进一步研究面瘫脑的信息交互情况，本文基于结构方程模型研究面部运 动系统的效应连接。首先使用结构方程模型驱动一个最优化的健康被试的效应连 接模型，然后将该模型运用到面瘫病人的数据集上。实验结果显示面部运动区域 中的效应连接发生改变，并且从面部运动系统到患侧小脑的自上而下的效应连接 发生紊乱。这项研究表明通过靶向特定的神经通路可能对面瘫临床上的治疗起一 定作用。 关键词：功能磁共振成像结构方程模型功能连接效应连接前扣带回 万方数据 摘要 11 万方数据 AbstractFunctional Abstract Functional magnetic resonance imaging(fMRI)is an important tool for studying the rehabilitation mechanism of Bell’S palsy(BP)．At present，researchers study BP by using functional connectivity．Functional connectivity only indirectly measures the correlation between brain regions．It is not able to reflect dynamic interactions between brain regions．So，it is insufficient to investigate the BP’S brain by simply using functional connectivity．Therefore，this article combines methods of functional and effective connectivity to study the brain network of BE In this article，the relationship Was studied between the functional connectivity strength of anterior cingulate cortex(ACC)and facial paralysis rehabilitation process． First，bilateral ACC was located as seed points based on the activation map in healthy individuals．Functional connectivity for bilateral ACC was then calculated with the whole brain based on the method of correlation analysis．The correlation between the strength of ACC’S connectivity with the rehabilitation process was finally acquired with analysis of covariance．The results demonstrated that functional connectivity of ACC ipsilateral to lesioned side was enforced as the recovery time prolonged．These findings suggested that the enforced connectivity modulated brain functional reorganization in the rehabilitation process，which played importa