建立银屑患者生存质量量表的研究-中西结合临床专业论文.docxVIP

建立银屑病患者生存质量量表的研究 建立银屑病患者生存质量量表的研究 中文摘要 目的：研制具有中医内涵的银屑惠者生存质量量表，全面、客观 的评价中医药治疗银屑病的临床疗效。 方法：根据WHO生存质量袁制定原则，结合中医基础理论，提 出量表的理论构想，广泛查阅国内外多种普遍性及银屑病专用生存 质量量表，采用结构化决策；的方法，构建初始量表。用调查的方 式对105名银屑病患者进行了测试，以离散趋势、条目答案频率分 布法、相关分析、因子分析等五种方法多维度筛选条目，最终形成 银屑病生存质量量表测试版(the Qlality of Life Scale for Psoriasis Patients-Prior Test Version，PQOLS)，并进行信度、效度和反应度 评价。 结果：研制出由生理、心理、社会3个维度共25条目组成的 PQOLS，与理论构想相符。PQOLS 24h后重测信度为0．975， Cronbach’sa系数为O．896，分半信度系数为O．870。因子分析提取了 6个公因子，累积方差贡献率56．324％，第一公因子为银屑病对日常 生活能力的影响，方差贡献率29．796％。各维度与总分相关系数于 0．760-0．945之间。PQOLS总分与SF～36总分、PASI总分、DLQI 总分的相关系数分别为．0．669，0．740、0．832。患者中医药治疗前后 PQOLS总分差已有统计学意义别，不同病情组、不同病程组、不同 年龄组、不同中医辩证分型组的患者PQOLS总分差异有统计学意 义。 结论：PQOLS见可靠、有效、灵敏的，同时具有中医特色，准 结论：PQOLS见可靠、有效、灵敏的，同时具有中医特色，准 确反映了银屑病患者生存质量的内涵，可作为银屑病中医临床疗效 评价的工具。 关键词：量表，银屑病，生存质量，中医 Development Development of Qlali姆of Life Scale for Psoriasis Patients ABSTRACT Objective：To develop the Traditional Chinese Medicine(TCM) characteristic quality of life(QOL)scale for completely and objectively evaluate the clinical effects of TCM on the patients with psoriasis． Methods：Conception of establishing the TCM characteristic quality of life scale was produced by WHO quality of life definition and TCM principle of treatment．The data of generic and psoriasis—specific quality of life scales and structured decisions were employed to establish the instnnnent before the item pool formed．The QOL data measured from 105 cases with psoriasis were used to evaluate the scale．Five methods(dispersion，responsibility，correlation analysis，factor analysis and SO on)were used in multidimensional selecting items and finally formed the Qlality of Life Scale for Psoriasis Patients-Prior Test Version (PQOLS)and evaluated the reliability and validity ofthe scale． Results：The developing PQOLS included three domains(physical， social，psychological)and 25 items that was consistent with the initial conception of establishing．After 24hour，the test-retest reliability and Cronbach’sc【coefficient and split-half reliabi