姜黄素固体制剂制备及其抗炎作用与机理研究-化学工程专业论文.docxVIP

广东工业大学硕士学位论文PV4的抗炎作用机制，结果表明，PV4能显著性降低由TPA促进过度表达的MMP．9、 广东工业大学硕士学位论文 PV4的抗炎作用机制，结果表明，PV4能显著性降低由TPA促进过度表达的MMP．9、 VEGF和Ⅲ一1B水平，能有效降低MIP一2、n眼a和IL-6水平，其可能是通过姜黄素抑 制NF—r,B通路中下游炎症因子及继发性炎症细胞因子发TNF．0t、IL-113、IL．6、MMP．9、 VEGF及MIP一2的表达，发挥抗炎的作用。 关键词：姜黄素：增溶；生物利用度；抗炎；保健食品 II 万方数据 AbslaactAbstract Abslaact Abstract Curcumin is the main active ingredient of the medicinal and edible plant，turmeric．It has good preventive and therapeutic effect against most of the clinical inflammation for its excellent anti—inflammatory activity in vitro and in vivo．The hJIgh oral doses of curcumin have no side effect on human body，which is of great significance for the development of new anti-inflammatory drugs and functional food．But curcLlmin has some disadvantages， including poor water solubility，low bioavailability and etc．，which limit the development of curcumin—containing anti-inflammatory agents and functional food．Therefore，in this study， we used 3 typical carriers to solubilize the curcumin through the solid dispersion techniques， and evaluates the solubility，dissolution，stability，pharmacokinetic and anti—inflammatory activity of these 3 curcumin solid preparations．This study may provide theoretical foundation for the development of curcumin-containging drugs and functional food． In this study,we chose three typical solubilization cartier,PVP,Poloxamer and HP-B-CD，and prepared the curcumin solid preparations through the solvent method，The result showed that all 3 carriers enhance the solubility and dissolution of curcumin，and also improve the stability and tolerance of curcuillin under the light，heat，alkali，metal ions and food additives．PVP showed the best improvement effect，Poloxamer the next．But the effect of liP-p—CD is not ideal． We use XRD，SEM,DSC and rTm,Raman and 1H-NMR characterization techniques to study the solubilizing mechanism．The results showed that the crystal structure of curcumin was changed in to the amorphous or molecular form after cartier package dispersion．The solubil