胶原壳聚糖基伤口敷料的制备及性能研究-皮革化学与工程专业论文.docxVIP

万方数据 万方数据 摘要 加，这种抑制作用更为明显。多孔支架能够促进红细胞聚集形成聚集体，堵住 血管破损处而达到止血的目的。成纤维细胞(Fbs)的毒性试验表明，多孔支架具 有良好的细胞相容性。 本文还利用生物相容性良好的丙烯酸类或明胶类胶粘剂，将复合膜与多孔 支架粘合在一起，制备了胶原/壳聚糖基双层伤口敷料。力学性能和透气性能表 明，丙烯酸类或明胶类胶粘剂对敷料整体的力学性能和透气性能影响较小。胶 原/壳聚糖基双层伤口敷料在伤口治疗方面具有广阔的应用前景。 关键词：胶原 壳聚糖 MFC 纳米 TiO2 多孔支架 II Abst Abstract Abstract Skin is the largest organ of the human body, which is a barrier to protect the body from disease and physical trauma, and helps to regulate the temperature and protect organs of our body and so on. Because of illness or burn, damage may happen to skin so serious that our body can not repair itself quickly. A large number of burned patients often died of infection and fluid loss. Therefore, appropriate wound dressing is very needed to replace the damaged skin. In this paper, imitating the structure and function of human skin, a double-layered structure of skin tissue engineering scaffolds is designed and made. The upper composite membrane of CS/PVA/MFC can effectively block invasion of outside bacteria and keep the wound at a suitable temperature and humidity. The lower porous scaffolds of collagen/chitosan/nano-TiO2 can provide nutrition and space for cell growth and migration, absorb the wound redundant exudate, avoid or reduce the inflammation and bacterial infection, to provide a clean and sterile environment for wound healing. In this paper, microfibrillated cellulose(MFC) was prepared from microcrystalline cellulose(MCC) by high pressure homogrnization after alkali pre-treatment. The MFC was then blended with chitosan (CS) and polyvinyl alcohol(PVA) to prepare CS/PVA/MFC composite membrane. The scanning electron microscopy(SEM) images of MFC showed a spider mesh three-dimensional network structure with the fiber diameter of about 100nm. The SEM of CS/PVA/MFC composite membrane showed the section of composite film gradually show a fibrous structure with the increase of percentage of MFC. The FTIR spectrum revealed the nanoscale MFC with CS and PVA formed a relatively strong hydro