姜黄素及其类似物对糖尿病并发症相关靶点生物活性的研究-有机化学专业论文.docxVIP

r卜i【1人学博士学位论文的抑制活性最高。抑制动力学研究表明姜黄素类化合物对Ⅱ．葡萄糖苷酶的抑制类型 r卜i【1人学博士学位论文 的抑制活性最高。抑制动力学研究表明姜黄素类化合物对Ⅱ．葡萄糖苷酶的抑制类型 为非竞争性抑制。构效关系研究表明rl于{Ij---酚羟基类姜黄素类似物百】能与a．糖苷 酶的结合最为紧密，从而表现出极好的抑制活性。 4．姜黄素类化合物的抗氧化性及对蛋白非酶糖基化的抑制作用 研究了天然姜黄素类化合物及其类似物对自由基清除的能力及蛋白非酶糖基化 的抑制作用。结果表明邻二酚羟基类姜黄素类似物(A2、B2、C2及D2)清除自由 基的能力及抑制非酶糖基化的作用均很强。非酶糖基化的抑制活性与清除自由基的 能力有‘定的相关性。 关键词：姜黄素、姜黄素类似物、糖尿病并发症、Ⅱ．葡萄糖苷酶抑制剂、醛糖还原 酶抑制剂、非酶糖基化抑制剂、抗氧化 中L【l大学博士学位论文Title：Studied 中L【l大学博士学位论文 Title：Studied on the activities of curcuminoids and curcumin analogs related to pathologies ofdiabetic complications Major：Organic Chemistry Author：Du Zhi—yun Supervisor：Prof．Gu Lion-quan Abstract Diabetes mellitus is a chronic prevalence disease with serious health problem The long．term elevated blood glucose levels characteristic of diabetes mellitus does harm to tissues and apparatus，and results in series of diabetic complications，that causes to menace the life and healthy of diabetes mellitus．旺．Glucosidase inhibitors，aldose reductase inhibitors，non-enzymatic protein glycation inhibitors and antioxidants proved to be benefit tO prevent or cure diabetes mel litus．However,drugs in clinic trials show some disadvantages，such as dissatisfactory curative effects and side effects．It is meaningful to find new drugs with higher activities f0r diabetes mellitus． Curcuminoids are the main component of Curcgtma Ionga，a traditional Chinese medicinal herb，with wide range of bioactivities，such antioxidant，anti·in flammatory， anticancer，and anti—HIV integrase activity．Cltrcttmt7 longa was recommended to use in Chinese traditional medical prescriptions against the diabetic complications，but the detail mechanism has not been done up tO now【n this study,the effects of the natural curcuminoids isolated from Curcuma longa and the synthetic curcumin analogs Ⅱ一glucosidase inhibition，aldose reductase inhibition，non·enzymatic protein glycation inhibition and free radical scavenging were evaluated in vitro The main works and results were sumerized as foIlows： 1．Curcuminoids isola