金葡液对冻干异体骨移植愈合影响的实验研究-外科学专业论文.docxVIP

中文擦要 目的:观察:金葡液对冻子异体管移榕愈合的影响 F 并探讨其作用机制。 方法; 24 只新西兰大自兔右侧挠营造成 15mm 缺挠模型，楼入冻二字异体膏，随机 分成商怨声部豁口只会术后第:台d 开始，实验经局部注射念萦液，对照结注毅等体糕 的坐海盐水。术后不同时间分别行 X 线片、组织学和放射性核紊背扫描检查#并黯定 血法钙、磷及碱性磷酸酶 (alkaHneI或l0sphatase ，ALP) 含爱培 结柴:实验级术后不同时闷的营代谢洁性、新营企成和血清?及 ALP 含蠢均离子 对照短，币1缸漓 Ca 低于对照怨。实验级异体管 90d 究金愈合声对照豁仍未愈合。 结论:冻子异体管作为一种生物支撑衬料，免疫 5灵性低，生物将容性好串余音§泼 作为…种促进骨折愈合药物 F 可有效加快?冻劳恋i干异体督§龄号愈合 关键海湾 余音辍§液:营移榕;管念合:冻二干F异体骨 lJ lJ Ahstract Objcctivc: To study the eff民t of Jinpuye on the healing of freeze-dri.ed bone allograft and explore its luechanism. ì\1ethods: 1、he 15n1nl segmental bone/periosteuln defects vVere created on right radius in 24 New Zealand rabbits ，fiUed with freeze-drìed bone allograft，and \vere treated \vith two groups randOlnl)飞 12 in each group. 丁en days af飞er operation，experimental group were iI飞jected wìth Jinpuye locally，control group were injected with saline. Observations \vere wíth X-ray，radionuclide bone irnaging histologìcaI examination as \vel1 as measurement of calciuln，phosphorus and alkaline phospha也se(ALP)in 妇umatdi能rent 如riods postoperatively. E这esuJts: The new bone formation，bone metabolic activity，amount ofphosphorus and ALP in serun1 were higher in experimental group than in that of control， but the level of serum calcìum was on the contrary. 妇le 企eeze dried-bone allograft healed in the 90th day in exper?lnental group，but did not healed in the s础ne time in control group. Conclusìons: As a suppo口ing biomaterial ，rfeezedried bone allograft has 10 immunogenicity and excellent biocompatibìlity.As a 企acture healing rnedicine ，Jinpuye promotes the new bone fornlation，accelerates the healing of freeze-dried bone allogra负 eff社cthFeiy. Key words: Jinpuye; Bone 位缸lsplantation; Bone-healing; Freeze-dried bone allograft; 郑重声明 本人的学位论文是在导师的指导下独立撰写并完成的，学位 论文没有裂窃、抄袭、造假等违反学术道德、学术规范和侵权行 为?本人愿承担由此而产生的法律后果和法律责任，特此郑重声 明。 学位论文作者〈签名):何锵 年甲妒?日 可 l 管移植是常科临床实践一种常用而有效的治疗方法 9 主要用于治疗管延迟愈合、 骨不迹及关节融合、管腔填塞或肿瘤切除术后背缺损等非传统的移植材料是自体霄 9 多取自能膏、胧膏、助骨以及肩 2甲骨声具有锋生成能力强步容易愈合的特点，临床应 用广泛非但由体管移植有许多缺点:取材有限，不能